{"id":41597,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-catestatina-un-peptido-endogeno-que-modula-el-receptor-nicotinico-neuronal\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"la-catestatina-un-peptido-endogeno-que-modula-el-receptor-nicotinico-neuronal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-catestatina-un-peptido-endogeno-que-modula-el-receptor-nicotinico-neuronal\/","title":{"rendered":"La catestatina, un peptido endogeno que modula el receptor nicotinico neuronal."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Mayorgas Quintana Ines Natalia <\/strong><\/h2>\n<p>Al igual que los opioides, varior p\u00e9ptidos derivados de la cromogramina a son co-almacenados y co-liberados junto con las catecolaminas durante el proceso exocit\u00f3tico de las catecolaminas. Uno de estos p\u00e9ptidos se llama catestatina, (cromogramina a344-364), es un p\u00e9ptido formado por 21 amino\u00e1cidos que bloquea la respuesta secretora de catecolaminas inducida a trav\u00e9s de la estimulaci\u00f3n del receptor nicot\u00ednico (nachr), lo que sugiere que catestatina puede ser un modulador end\u00f3geno de la liberaci\u00f3n de catecolaminas actuando a nivel del nachr. para estudiar esta hip\u00f3tesis, hemos estudiado los efectos de catestatina sobre las cin\u00e9ticas de las corrientes de entrada a trav\u00e9s de los nachr en c\u00e9lulas cromafines bovinas mediante la t\u00e9cnica de \u00abpacth-clamp\u00bb en su configuraci\u00f3n de c\u00e9lula entera. La aplicaci\u00f3n de pulsos intermitentes de ach (100 um, 1-s cada 30-s) provova corrientes reproducibles a trav\u00e9s del nachr. La catestatina es capaz de bloquear estas corrientes (iach) de forma concentraci\u00f3n-dependiente (ci50=15 um). el bloqueo de la iach por catestatina se produce de forma muy r\u00e1pida (ton=64 ms) as\u00ed como la recuperaci\u00f3n de la corriente nicot\u00ednica (toff=60.6 ms) tras el lavado de la catestatina.  parece muy probable que catestatina se una a la cara extracelular del nachr, ya que a pesar de dializar la c\u00e9lula con catestatina, nose ocluye el bloqueo de la iach por la superfusi\u00f3n de la c\u00e9lula con el p\u00e9ptido. A concentraciones de ach crecientes, la catestatina tiene un comportamiento compatible con un antagonismo competitivo. El grado de bloqueo de la iach por catestatina (10 um), es similar a todos los potenciales de membrana estudiados(-100 \/ 0 mv); este comportamiento es similar al de la dihidro-beta-erytroidina (antagonista competitivo del nachr), pero difiere del fuerte comportamiento voltaje-dependiente del hexametonio (antagonista no-competitivo del nachr). Estas caracter\u00edsticas del bloqueo de la iach h<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La catestatina, un peptido endogeno que modula el receptor nicotinico neuronal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La catestatina, un peptido endogeno que modula el receptor nicotinico neuronal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Mayorgas Quintana Ines Natalia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Garcia Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez Garc\u00eda <\/li>\n<li>salvador Uniegra bover (vocal)<\/li>\n<li>Francisco Sala merchan (vocal)<\/li>\n<li>valent\u00edn Ce\u00f1a callejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mayorgas Quintana Ines Natalia Al igual que los opioides, varior p\u00e9ptidos derivados de la cromogramina a son [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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