{"id":41601,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicacion-del-factor-de-necrosis-tumoral-alfa-en-la-genesis-del-estado-de-circulacion-hiperdinamica-en-un-modelo-experimental-de-hp\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"implicacion-del-factor-de-necrosis-tumoral-alfa-en-la-genesis-del-estado-de-circulacion-hiperdinamica-en-un-modelo-experimental-de-hp","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/implicacion-del-factor-de-necrosis-tumoral-alfa-en-la-genesis-del-estado-de-circulacion-hiperdinamica-en-un-modelo-experimental-de-hp\/","title":{"rendered":"Implicacion del factor de necrosis tumoral alfa en la genesis del estado de circulacion hiperdinamica en un modelo experimental de hp."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Mu\u00f1oz Arredondo <\/strong><\/h2>\n<p>Investigar la implicaci\u00f3n del fnt-alpha en la g\u00e9nesis del estado de circulaci\u00f3n hiperdin\u00e1mica en la hp y estudiar los factores que median la acci\u00f3n hemodin\u00e1mica de la citocina en este contexto. El estudio se realiz\u00f3 en un modelo animal de rata con hp por estenosis de la vena porta. Se inyectaron anticuerpos anti-fnt-alpha o placebo a ratas en fase inicial o avanzada de la hp. la administraci\u00f3n a corto plazo de los anticuerpos reverti\u00f3 la hiperhemia sist\u00e9mica y atenu\u00f3 la espl\u00e1cnica, aunque no modific\u00f3 la presi\u00f3n portal. La administraci\u00f3n de los anticuerpos a largo plazo s\u00f3lo atenu\u00f3 la hiperhemia sist\u00e9mica, mientras que no modific\u00f3 ni la hiperhemia espl\u00e1cnica ni el grado de formaci\u00f3n de colaterales portosist\u00e9micas.  tambi\u00e9n investigamos la respuesta hemodin\u00e1mica de los animales con hp a la administraci\u00f3n de inhibidores del \u00f3xido n\u00edtrico y de la prostaciclina. los incrementos relativos observados en la resistencia vascular sist\u00e9mica y en la presi\u00f3n arterial media tras la administraci\u00f3n de los inhibidores fueron menores en los animales tratados con anticuerpos, tanto a corto como a largo plazo. as\u00ed mismo, los anticuerpos provocaron un descenso en los niveles s\u00e9ricos de fnt-alpha, nitratos\/nitritos y 6-keto-pgf 1-alpha. Los niveles s\u00e9ricos de glucag\u00f3n aumentaron tras el tratamiento a largo plazo. Se observ\u00f3 una correlaci\u00f3n entre la presi\u00f3n arterial media y los niveles s\u00e9ricos de fnt-alpha parece jugar un papel relevante en la g\u00e9nesis del estado de circulaci\u00f3n hiperdin\u00e1mica asociado a la hipertensi\u00f3n portal y que su efecto es mediado por un incremento en la s\u00edntesis de los vasodilatadores endoteliales \u00f3xido n\u00edtrico y prostaciclina. El mantenimiento de la hiperhemia espl\u00e1cnica tras la inhibici\u00f3n a largo plazo podr\u00eda deberse a un mecanismo compensatorio de liberaci\u00f3n de glucag\u00f3n..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicacion del factor de necrosis tumoral alfa en la genesis del estado de circulacion hiperdinamica en un modelo experimental de hp.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicacion del factor de necrosis tumoral alfa en la genesis del estado de circulacion hiperdinamica en un modelo experimental de hp. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Mu\u00f1oz Arredondo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Agust\u00edn Albillos Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: valent\u00edn Cuervas-mons mart\u00ednez <\/li>\n<li>melchor Alvarez de mon soto (vocal)<\/li>\n<li>Juan  Jos\u00e9 Arag\u00f3n reyes (vocal)<\/li>\n<li>Antonio De la hera mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Mu\u00f1oz Arredondo Investigar la implicaci\u00f3n del fnt-alpha en la g\u00e9nesis del estado de circulaci\u00f3n hiperdin\u00e1mica en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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