{"id":41603,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significado-clinico-biologico-de-la-expresion-de-veg-vpf-en-meningiomas-intracraneales\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"significado-clinico-biologico-de-la-expresion-de-veg-vpf-en-meningiomas-intracraneales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/significado-clinico-biologico-de-la-expresion-de-veg-vpf-en-meningiomas-intracraneales\/","title":{"rendered":"Significado clinico-biologico de la expresion de veg\/vpf en meningiomas intracraneales."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Pedrosa Sanchez <\/strong><\/h2>\n<p>La patogenia del edema cerebral que acompa\u00f1a a muchas neoplasias cerebrales viene siendo estudiada desde hace varios a\u00f1os, debido a sus importantes implicaciones sobre el comportamiento biol\u00f3gico, repercusi\u00f3n cl\u00ednica y el pron\u00f3stico de estos tumores. Se han planteado diversas teor\u00edas, con participaci\u00f3n de m\u00faltiples factores anatomo-cl\u00ednicos, sin haber llegado a\u00fan a establecerse una relaci\u00f3n clara con alg\u00fan acontecimiento biol\u00f3gico concreto.  el objetivo de este trabajo es demostrar el relevante papel de una nueva mol\u00e9cula pept\u00eddica, el veg\/vpf (factor de crecimiento endotelial y de permeabilidad vascular), en el desarrollo de dicho edema peritumoral en una serie de 34 meningiomas intracraneales. Asimismo, hemos pretendido observar la relaci\u00f3n entre la actividad de esta prote\u00edna con otro fen\u00f3meno de gran trascendencia en el crecimiento de estos tumores, como es su neovascularizaci\u00f3n o antiog\u00e9nesis.  pro \u00faltimo, se ha analizado la posible influencia de la administraci\u00f3n de dexametasona sobre la expresi\u00f3n del veg\/vpf en la muestra de meningiomas seleccionados. Para completar dicho an\u00e1lisis, tambi\u00e9n se realiz\u00f3 un estudio paralelo sobre un modelo de tumor experimental murino.  en la metodolog\u00eda del presente estudio, nos hemos basado fundamentalmente en el empleo de t\u00e9cnicas inmunohistoqu\u00edmicas, de morfometr\u00eda, as\u00ed como los estudios de reuroimagen oportunos, en especial la rm.  a la vista de los resultados obtenidos, podemos concluir de este trabajo los siguientes puntos de mayor inter\u00e9s: 1) se puede detectar expresi\u00f3n de veg\/vpf en un alto porcentaje de meningiomas; 2) existe una correlaci\u00f3n lineal entre el grado de expresi\u00f3n del p\u00e9ptido y el grado de edema peritumoral, as\u00ed como con el \u00e1rea vascular endotelial (angiog\u00e9nesis); 3) no existe una influencia significativa de la dexametasona sobre la expresi\u00f3n de veg\/vpf en los meningiomas.  como planteamiento final, queremos se\u00f1alar la po<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significado clinico-biologico de la expresion de veg\/vpf en meningiomas intracraneales.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significado clinico-biologico de la expresion de veg\/vpf en meningiomas intracraneales. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Pedrosa Sanchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Vaquero Crespo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Garcia  sancho martin <\/li>\n<li>Santiago Coca menchero (vocal)<\/li>\n<li>Santiago Oya otero (vocal)<\/li>\n<li>gonzalo Bravo zabalgoitia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Pedrosa Sanchez La patogenia del edema cerebral que acompa\u00f1a a muchas neoplasias cerebrales viene siendo estudiada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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