{"id":41609,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-in-vitro-e-in-vivo-del-triflusal-sobre-la-interaccion-de-los-neutrofilos-con-las-plaquetas-mecanismos-mediados-y-no-mediados-por-el-oxido-nitrico\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efectos-in-vitro-e-in-vivo-del-triflusal-sobre-la-interaccion-de-los-neutrofilos-con-las-plaquetas-mecanismos-mediados-y-no-mediados-por-el-oxido-nitrico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-in-vitro-e-in-vivo-del-triflusal-sobre-la-interaccion-de-los-neutrofilos-con-las-plaquetas-mecanismos-mediados-y-no-mediados-por-el-oxido-nitrico\/","title":{"rendered":"Efectos in vitro e in vivo del triflusal sobre la interaccion de los neutrofilos con las plaquetas. mecanismos mediados y no mediados por el oxido nitrico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Alfonso Rico  Zalba <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os se ha ido elaborando de forma progresiva el concepto de la trombosis como un acontecimiento multicelular en el cual las interacciones c\u00e9lula a c\u00e9lula entre plaquetas, neutr\u00f3filos y endotelio regulan el tama\u00f1o y crecimiento del trombo. Partiendo de que parte de los efectos de la asprina en la isquemia mioc\u00e1rdica tienen lugar a trav\u00e9s de la interacci\u00f3n de los netr\u00f3filos con las plaquetas mediada por el \u00f3xido n\u00edtrico (no), en esta tesis se estudia el papel de otro antiagregante plaquetario, el triflusal, sobre dicha interacci\u00f3n.  la investigaci\u00f3n se ha llevado a cabo in vitro y posteriormente se ha comprobado su importancia in vivo administrando triflusal a voluntarios sanos. En la parte in vivo tambi\u00e9n se ha estudiado el fecto del triflusal sobre la secrecci\u00f3n plaquetaria de tgf-beta en ausencia de agregaci\u00f3n.  los resultados muestran que el triflusal ejerce un efecto antiagregante plaquetario por medio de su acci\u00f3n a trav\u00e9s de los neutr\u00f3filos y que \u00e9stos no ejercen en ausencia de triflusal. dicho efecto est\u00e1 mediado por el \u00f3xido n\u00edtrico (no) que liberan los neutr\u00f3filos en presencia de triflusal y en el mismo est\u00e1 implicado el gmpc. Esta acci\u00f3n de triflusal se ve favorecida por su metabolito, el htb, ya que \u00e9ste facilita la acumulaci\u00f3n de gmpc en las plaquetas. Por los que se refiere a la secreci\u00f3n plaquetaria, el triflusal no tiene acci\u00f3n directa sobre la misma aunque \u00e9sta si se ve inhibida por los neutr\u00f3filos tratados con triflusal y en esta inhibici\u00f3n no est\u00e1 implicado el no..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos in vitro e in vivo del triflusal sobre la interaccion de los neutrofilos con las plaquetas. mecanismos mediados y no mediados por el oxido nitrico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos in vitro e in vivo del triflusal sobre la interaccion de los neutrofilos con las plaquetas. mecanismos mediados y no mediados por el oxido nitrico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Alfonso Rico  Zalba <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li> Gutierrez fuentes Jos\u00e9 Antonio (vocal)<\/li>\n<li>pedro S\u00e1nchez Garc\u00eda (vocal)<\/li>\n<li>Juli\u00e1n Garcia rafanell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Alfonso Rico Zalba En los \u00faltimos a\u00f1os se ha ido elaborando de forma progresiva el concepto [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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