{"id":41638,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelo-experimental-de-artropatia-degenerativa-en-raton-transgenico\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"modelo-experimental-de-artropatia-degenerativa-en-raton-transgenico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelo-experimental-de-artropatia-degenerativa-en-raton-transgenico\/","title":{"rendered":"Modelo experimental de artropatia degenerativa en raton transgenico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Carmen Fernandez Criado <\/strong><\/h2>\n<p>El modelo experimental cursa con una lesi\u00f3n, con expresi\u00f3n inmunol\u00f3gica tisular y celular, con repercusiones multiorg\u00e1nicas y multi-tisulares, con granulomas de tipo histiocitario y vasculitis.  en el cart\u00edlago articular se manifiesta mediante una lesi\u00f3n que afecta a la arquitectura del cart\u00edlago articular, con hipocelularidad, hipocromasia, alteraciones de fenotipo celular, -todos ellos criterios histol\u00f3gicos de osteoartritis-.  los condrocitos muestran aumento de la actividad celular inespec\u00edfica (aumenta agnors), disminuci\u00f3n de su capacidad de entrar en ciclo celular (disminuye pcna), disminuyendo su capacidad de bloque al proceso de muerte celulas (disminuye bcl2), aumentando los elementos (aumento tnf alfa), que favorecen el proceso de muerte celular (aumenta apoptosis), acompa\u00f1andose de incapacidad de las c\u00e9lulas responsables en producir de forma organizada los elementos osteoides m\u00e1s primitivos (anomal\u00edas de la calcificaci\u00f3n), dando lugar a la disminuci\u00f3n, y alteraciones, de la arquitectura, en el hueso subcondral, que se acompa\u00f1a de hipocelularidad (disminuyen osteoblastos), y de hipovascularidad (disminuye el patr\u00f3n vascular); sin poder establecer en moemento alguno relaci\u00f3n causa-efecto de la lesi\u00f3n del hueso subcondral con el proceso de osteoartritis..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelo experimental de artropatia degenerativa en raton transgenico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelo experimental de artropatia degenerativa en raton transgenico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Carmen Fernandez Criado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Delgado Baeza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Herruzo cabrera <\/li>\n<li>mercedes Patron romero (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Blanquez layunta (vocal)<\/li>\n<li>Alberto Jimenez ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Carmen Fernandez Criado El modelo experimental cursa con una lesi\u00f3n, con expresi\u00f3n inmunol\u00f3gica tisular y celular, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,213,156,1323],"tags":[49266,15407,105329,78480,14401,8545],"class_list":["post-41638","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-osteopatologia","category-patologia","category-patologia-experimental","tag-alberto-jimenez-ruiz","tag-emilio-delgado-baeza","tag-m-carmen-fernandez-criado","tag-maria-jose-blanquez-layunta","tag-mercedes-patron-romero","tag-rafael-herruzo-cabrera"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41638","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=41638"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41638\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=41638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=41638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=41638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}