{"id":41646,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-17betaestradiol-estimula-la-expresion-de-la-oxido-nitrico-sintasa-neuronal-en-neutrofilos-humanos-implicacion-en-la-agrecacion-plaquetaria\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"el-17betaestradiol-estimula-la-expresion-de-la-oxido-nitrico-sintasa-neuronal-en-neutrofilos-humanos-implicacion-en-la-agrecacion-plaquetaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-17betaestradiol-estimula-la-expresion-de-la-oxido-nitrico-sintasa-neuronal-en-neutrofilos-humanos-implicacion-en-la-agrecacion-plaquetaria\/","title":{"rendered":"El 17betaestradiol estimula la expresion de la oxido nitrico sintasa neuronal en neutrofilos humanos. implicacion en la agrecacion plaquetaria."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gema Garcia Galvez <\/strong><\/h2>\n<p>La baja incidencia de cardipat\u00eda isoqu\u00e9mica en la poblaci\u00f3n de sexo femenino durante su edad f\u00e9rtil, junto con el progresivo aumento de la enfermedad cardiovascular a partir de la menopausia, parece estar relacionado con las hormonas femeninas. los mecanismos mediante los cuales el tratamiento hormonal sustitutivo con estrogenos ejerce sus efectos beneficiosos a nivel cardiovascular son multifactoriales. de entre ellos destacan las acciones directas sobre la pared vascular con la documentada vasodilataci\u00f3n endotelio-dependiente o mediada por \u00f3xido n\u00edtrico, conociendo que otras c\u00e9lulas como los neutr\u00f3filos expresan la maquinaria enzim\u00e1tica del \u00f3xido n\u00edtrico, as\u00ed como receptores estrog\u00e9nicos, el prop\u00f3sito de esta tesis fue valorar la posible regulaci\u00f3n estrog\u00e9nica de la producci\u00f3n de \u00f3xido n\u00edtrico por los neutr\u00f3ficos humanos in vitro y en pacientes postmenop\u00e1usicas antes y despues de una terapia hormonal sustitutiva. pacientes y m\u00e9todo: 1. Estudios in vitro con neutrofilos de 10 voluntarios sanos varones, as\u00ed como con plasma rico en plaquetas de estos mismos donantes. 2. Estudios in vivo con neutrofilos de 10 pacientes menop\u00e1usicas antes y despues de utilizar una terapia estrog\u00e9nica. Resultados: 1. El 17betaestradiol estimula la expresi\u00f3n de la \u00f3xido n\u00edtrico sintasa neuronal (nosn) en los neutrofilos humanos, incrementando su capacidad para producir \u00f3xido n\u00edtrico (no). 2. El 17betaestradiol estimula la expresi\u00f3n del receptor estrog\u00e9nico en neutrofilos humanos. 3. La expresi\u00f3n de la nosn en neutrofilos humanos es mediada por los estr\u00f3genos a trav\u00e9s de un mecanismo receptor-dependiente. 4. El no que liberan los neutrofilos estimulados por 17betaestradiol tiene efectos antiagregantes plaquetarios, acompa\u00f1\u00e1ndose de un aumento en el contenido de gmpc plaquetar. 5. La expresi\u00f3n de la nosn y del receptor estrog\u00e9nico en los neutrofilos de las mujeres postratamiento esdrog\u00e9nico se vi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El 17betaestradiol estimula la expresion de la oxido nitrico sintasa neuronal en neutrofilos humanos. implicacion en la agrecacion plaquetaria.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El 17betaestradiol estimula la expresion de la oxido nitrico sintasa neuronal en neutrofilos humanos. implicacion en la agrecacion plaquetaria. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gema Garcia Galvez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin D\u00edaz Recasens<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Fernandez-villoria <\/li>\n<li>jeronimo Farre muncharaz (vocal)<\/li>\n<li> Vidant aragon Jos\u00e9 Antonio (vocal)<\/li>\n<li>Jos\u00e9 Manuel Bajo arenas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gema Garcia Galvez La baja incidencia de cardipat\u00eda isoqu\u00e9mica en la poblaci\u00f3n de sexo femenino durante su [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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