{"id":41651,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/riesgo-genetico-en-trombosis-a-proposito-del-factor-v-leiden\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"riesgo-genetico-en-trombosis-a-proposito-del-factor-v-leiden","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/riesgo-genetico-en-trombosis-a-proposito-del-factor-v-leiden\/","title":{"rendered":"Riesgo genetico en trombosis: a proposito del factor v leiden."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ruben Gomez Rioja <\/strong><\/h2>\n<p>El fenotipo de resistencia a la porte\u00edna c activada (rpca) y su principal base gen\u00e9tica, el factor v leiden, son actualmente la alteraci\u00f3n m\u00e1s frecuentemente encontrada en pacientes con trombofilia venosa. Para evaluar el riesgo de trombosis venosa o arterial asociado bien a la presencia del fenotipo rpca o a la de factor v leiden se realiza un estudio observacional prospectivo con dise\u00f1o de casos y controles. durante los a\u00f1os 1996-97 se seleccionan un grupo control de 131 sujetos sin antecedentes de trombosis y dos grupos de casos de trombosis venosa (n=158) o arterial (n=107). La preValencia de la mutaci\u00f3n factor v leiden en poblaci\u00f3n normal de nuestra area es de 3,8%. La preValencia en pacientes con trombosis venosa es de un 14,6%, en pacientes con trombosis arterial de un 3,7%. El fenotipo rpca y el genotipo heterozigoto factor v leiden se asocian significativamente a un incremento de riesgo para la aparici\u00f3n de enfermedad tromboemb\u00f3lica venosa de odds ratio 2 y 5 respectivamente. No encontramos asociaci\u00f3n con la aparici\u00f3n de trombosis arterial. observamos que la aparici\u00f3n de un fenotipo de rpca en un test basado en ttpa depende principalmente del genotipo factor v leiden, pero otras condiciones, como la elevaci\u00f3n del factor viii o un ttpa de base acortada pueden condicionar la aparici\u00f3n de un fenotipo rpca adquirido. El fenotipo rpca no debido a factor v leiden se asocia a un ligero incremento del riesgo de trombosis venosa. En el grupo de pacientes con trombosis venosa se encontraron factores de base gen\u00e9tica en un 24% de los casos, de los cuales un 60% eran el factor v leiden. Los pacientes portadores de factor v leiden presentan una mayor edad de aparici\u00f3n de la trombosis y menor n\u00famero de recurrencia que los pacientes portadores de otras alteraciones trombof\u00edlicas..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Riesgo genetico en trombosis: a proposito del factor v leiden.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Riesgo genetico en trombosis: a proposito del factor v leiden. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ruben Gomez Rioja <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Jos\u00e9 V\u00e1zquez Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>eduardo Ros die (vocal)<\/li>\n<li>Francisco Javier Batlle fontrodona (vocal)<\/li>\n<li> Jimenez cossio Jos\u00e9 Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ruben Gomez Rioja El fenotipo de resistencia a la porte\u00edna c activada (rpca) y su principal base [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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