{"id":41667,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/construccion-y-estudio-de-vectores-retrovirales-portadores-de-toxinas-para-el-tratamiento-de-tumores-cerebrales-por-terapia-genica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"construccion-y-estudio-de-vectores-retrovirales-portadores-de-toxinas-para-el-tratamiento-de-tumores-cerebrales-por-terapia-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/construccion-y-estudio-de-vectores-retrovirales-portadores-de-toxinas-para-el-tratamiento-de-tumores-cerebrales-por-terapia-genica\/","title":{"rendered":"Construccion y estudio de vectores retrovirales portadores de toxinas para el tratamiento de tumores cerebrales por terapia genica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Veronica Martin Garcia <\/strong><\/h2>\n<p>Esta tesis presenta la construcci\u00f3n de distintos vectores retrovirales con objeto de estudiar la viabilidad de un sistema retroviral portador de genes cuya expresi\u00f3n sea regulable. dicha regulaci\u00f3n se abord\u00f3 mediante dos promotores, uno espec\u00edfico de especie (el promotor del adn ribos\u00f3mico humano) y otro regulable mediante la hormona tiroidea (el promotor de la prote\u00edna b\u00e1sica de la mielina de rat\u00f3n).  se obtuvo una expresi\u00f3n espec\u00edfica de especie (humana) del gen de la luciferasa a partir del promotor del adn ribos\u00f3mico humano seguido del ires del virus de la encefalomiocarditis, en experimentos de transfecciones transitorias.  el sistema basado en el segundo promotor permiti\u00f3 obtener clones de c\u00e9lulas productoras con una regulaci\u00f3n de la expresi\u00f3n de la luciferasa absoluta. se obtuvieron c\u00e9lulas productoras de retrovirus portadores de genes t\u00f3xicos cuya expresi\u00f3n se activaba en presencia de la hormona tiroidea, llegando a eliminar un tumor cerebral inducido de 60mm3 de volumen en una rata wistar.  la terapia g\u00e9nica retroviral basada en la expresi\u00f3n selectiva de genes t\u00f3xicos en las c\u00e9lulas tumorales en presencia de hormona tiroidea se presenta como una nueva perspectiva para el tratamiento de tumores cerebrales malignos..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Construccion y estudio de vectores retrovirales portadores de toxinas para el tratamiento de tumores cerebrales por terapia genica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Construccion y estudio de vectores retrovirales portadores de toxinas para el tratamiento de tumores cerebrales por terapia genica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Veronica Martin Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Izuierdo Rojo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Valdivieso <\/li>\n<li>Mar\u00eda Izquierdo jose (vocal)<\/li>\n<li>roser Gonzalez (vocal)<\/li>\n<li>Santiago Ramon y cajal ag\u00ed\u00bceras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Veronica Martin Garcia Esta tesis presenta la construcci\u00f3n de distintos vectores retrovirales con objeto de estudiar la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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