{"id":41700,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":""},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"expresion-y-distribucion-en-el-cerebelo-del-receptor-inositol-145-trisfosfato-del-receptor-n-metil-d-aspartato-de-las-enzimas-neuronal-e-inducible-de-la-oxido-nitrico-sintasa-y-de-la-nitrotirosina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/expresion-y-distribucion-en-el-cerebelo-del-receptor-inositol-145-trisfosfato-del-receptor-n-metil-d-aspartato-de-las-enzimas-neuronal-e-inducible-de-la-oxido-nitrico-sintasa-y-de-la-nitrotirosina\/","title":{"rendered":"Expresion y distribucion en el cerebelo del receptor inositol-1,4,5-trisfosfato del receptor n-metil-d-aspartato, de las enzimas neuronal e inducible de la oxido nitrico sintasa y de la nitrotirosina en proteinas en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez De Velasco Hernandez Javier <\/strong><\/h2>\n<p>El presente trabajo se realiza en base a un nuevo modelo de hipoxiareperfusi\u00f3n para analizar la distribuci\u00f3n y expresi\u00f3n de los receptores inositol-18485-trisfosfato y n-metil-d-aspartato (insp3-r y nmda-r respectivamente), de los enzimas neuronal (nnos) e inducible (inos) de la \u00f3xido n\u00edtrico sintasa y de la nitrotirosina en prote\u00ednas en el cerebelo de ratas normales. tras varios periodos de tiempo de reperfusi\u00f3n, despu\u00e9s de provocar los 30 minutos de hipoxia, se analizan los cambios sufridos por estas sustancias neuroactivas en los componentes neuronales del cerebelo. Este \u00f3rgano, el cual es el m\u00e1s sensible a la hipoxia, sufre variaciones a la baja de ambos receptores, insp3-r y nmda-r y cambios alternativos en la expresi\u00f3n de nnos y de inos representados estos en general y tras la hipxiapor un descenso de la nnos y un incremento de la inos. La aparici\u00f3n de nitrotirosina en prote\u00ednas se mantiene a lo largo de todo el periodo de reperfusi\u00f3n.  se concluye que el modelo experimental presentado es v\u00e1lido para canocer las variaciones en expresi\u00f3n de las sustancias neuroactivas citadas, indicando que los componentes del cerebelo siguen funcionalmente activos durante la experimentaci\u00f3n.  algunas de las sustancias sometidas a estudio en este trabajo no cuentan con antecedentes sobre su participaci\u00f3n en procesos de hipoxia-reperfusi\u00f3n. otras, como las isoformas neuronal e inducible de la \u00f3xido n\u00edtrico sintasa han sido previamente analizadas en otros modelos de hipoxia y otra como la nitrotirosina en prote\u00ednas nuca fue analizada bajo estas condiciones aunque si lo fue en procesos de envejecimiento cerebral..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion y distribucion en el cerebelo del receptor inositol-1,4,5-trisfosfato del receptor n-metil-d-aspartato, de las enzimas neuronal e inducible de la oxido nitrico sintasa y de la nitrotirosina en proteinas en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion y distribucion en el cerebelo del receptor inositol-1,4,5-trisfosfato del receptor n-metil-d-aspartato, de las enzimas neuronal e inducible de la oxido nitrico sintasa y de la nitrotirosina en proteinas en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez De Velasco Hernandez Javier <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Rodrigo Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fernandez <\/li>\n<li> Leza cerro Juan  Carlos (vocal)<\/li>\n<li>ricardo Martinez murillo (vocal)<\/li>\n<li>Mar\u00eda Santacana altimiras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez De Velasco Hernandez Javier El presente trabajo se realiza en base a un nuevo modelo de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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