{"id":41702,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/significado-clinico-de-las-mutaciones-en-el-genoma-del-vih-1-asociadas-a-resistencias-a-los-analogos-de-nucleosidos\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"significado-clinico-de-las-mutaciones-en-el-genoma-del-vih-1-asociadas-a-resistencias-a-los-analogos-de-nucleosidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/significado-clinico-de-las-mutaciones-en-el-genoma-del-vih-1-asociadas-a-resistencias-a-los-analogos-de-nucleosidos\/","title":{"rendered":"Significado clinico de las mutaciones en el genoma del vih-1 asociadas a resistencias a los analogos de nucleosidos."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Gomez Cano Alfaro Mar\u00eda <\/strong><\/h2>\n<p>Objetivo: significado cl\u00ednico de la presencia de mutaciones asociadas a resistencia a los farmacos antirretrovirales en individuos vih-1 +.  an\u00e1lisis de la relaci\u00f3n entre estas mutaciones y diferentes marcadores virol\u00f3gicos e inmunol\u00f3gicos, examen de la aplicabilidad cl\u00ednica.  resultados y conclusiones: un reducido grupo de pacientes tratados con zdv en monoterapia se mantienen con beneficio cl\u00ednico e inmunol\u00f3gico durante m\u00e1s de cinco a\u00f1os.  no hay evidencia de un incremento en la preValencia de resistencias primarias a los an\u00e1logos de mucleosidos al comparar pacientes \u00abnaive\u00bb de 1993 y 1997 (15%).  relaci\u00f3n entre progresi\u00f3n r\u00e1pida de la enfermedad y la aparici\u00f3n de la mutaci\u00f3n en el codon 215.  en pacientes tratados con al menos dos an\u00e1logos de nucleosidos durante como m\u00ednimo un a\u00f1o aparecen mutaciones asociadas a zdv y\/o 3tc en el 90%. Un 18% de los pacientes pretratados con ddi o ddc presentaron m184v. en cambio en los pacientes expuestos a ddi y ddc la preValencia de mutaciones asociadas a resistencia a ellos fue baja (inferior al 15%).  en pacientes tratados con triple terapia se ha observado que la mutaci\u00f3n en la posici\u00f3n 184 aparece m\u00e1s tarce que en pacientes con biterapia.  en el an\u00e1lisis de genotipos multirresistentes circulantes en espa\u00f1a se encontr\u00f3 que un 2% de pacientes pretratados presentaron el cambio q151m.  la ausencia de emergencia de resistencia en pacientes con carga viral detectable se podr\u00eda explicar con la hip\u00f3tesis de viremia residual..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Significado clinico de las mutaciones en el genoma del vih-1 asociadas a resistencias a los analogos de nucleosidos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Significado clinico de las mutaciones en el genoma del vih-1 asociadas a resistencias a los analogos de nucleosidos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Gomez Cano Alfaro Mar\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Vicente Soriano Vazquez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Manuel (secretario) Leal noval <\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<li>Juan Gonzalez lahoz (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gomez Cano Alfaro Mar\u00eda Objetivo: significado cl\u00ednico de la presencia de mutaciones asociadas a resistencia a los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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