{"id":41704,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-eficacia-antiviral-frente-al-vih-1-de-la-proteina-de-fusion-cd4-toxina-difterica-dab389cd4-y-analisis-de-su-mecanismo-de-inmunosupresion\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-la-eficacia-antiviral-frente-al-vih-1-de-la-proteina-de-fusion-cd4-toxina-difterica-dab389cd4-y-analisis-de-su-mecanismo-de-inmunosupresion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estudio-de-la-eficacia-antiviral-frente-al-vih-1-de-la-proteina-de-fusion-cd4-toxina-difterica-dab389cd4-y-analisis-de-su-mecanismo-de-inmunosupresion\/","title":{"rendered":"Estudio de la eficacia antiviral frente al vih-1 de la proteina de fusion cd4-toxina difterica dab389cd4 y analisis de su mecanismo de inmunosupresion."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Martin Serrano <\/strong><\/h2>\n<p>Dab389cd4 es una inmunotoxina en la que se ha sustituido el dominio receptor de la toxina dift\u00e9rica por los dominios d1 y d2 del cd4 humano, de forma que la prote\u00edna resultante elimina selectivamente las c\u00e9lulas infectadas por el vih, ya que el dominio 1 de cd4 interacciona con la prote\u00edna de la envuelta del vih, gp120, la cual se expresa en la membrana de las c\u00e9lulas infectadas por el virus. En la presente tesis doctoral se describe la actividad antiviral frente al vih de dab389cd4 y tambi\u00e9n se describe el mecanismo de inmunosupresi\u00f3n de la inmunotoxina. En la tesis se demuestra que dab389cd4 tiene una actividad anti-vih muy potente en linfocitos aislados de pacientes con sida, en los cuales erradica las c\u00e9lulas infectadas pro el vih de forma selectiva. Tambi\u00e9n se demuestra que dab389cd4 es activa frente a macr\u00f3fagos infectados por el vih y que no es t\u00f3xica para es poblaci\u00f3n celular, describi\u00e9ndose tambi\u00e9n que existe un fuerte efecto sin\u00e9rgico entre dab389cd4 y el inhibidor de la protesa del vih ritonavir. Tambi\u00e9n hemos analizado la eficacia antiviral de dab389cd4 en el modelo animal hu-pbl-scid y observamos que la inmunotoxina disminuye la carga viral del vih en los ratones infectados. Cuando hemos estudiado el efecto de dab389cd4 en la activaci\u00f3n linfocitaria observamos que dab389cd4 tiene un efecto inmunosupresor in vitro cuando los linfocitos son activados a trav\u00e9s del complejo tcr-cd3 debido a la inhibici\u00f3n de la producci\u00f3n de interleuquina 2 en el cultivo. Finalmente, demostramos que dab389cd4 tiene una conformaci\u00f3n dim\u00e9rica en soluci\u00f3n que le permite interaccionar in vitro con mol\u00e9culas hla de clase ii con mayor afinidad que las formas solubles de cd4 y este hecho explicar\u00eda el efecto inmunosupresor descrito..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la eficacia antiviral frente al vih-1 de la proteina de fusion cd4-toxina difterica dab389cd4 y analisis de su mecanismo de inmunosupresion.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la eficacia antiviral frente al vih-1 de la proteina de fusion cd4-toxina difterica dab389cd4 y analisis de su mecanismo de inmunosupresion. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Martin Serrano <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Alcami Pertejo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Carrasco llamas <\/li>\n<li>Rafael Rubio Garc\u00eda (vocal)<\/li>\n<li>balbino Jos\u00e9 Alarcon sanchez (vocal)<\/li>\n<li>Jes\u00fas Fominaya gutierrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Martin Serrano Dab389cd4 es una inmunotoxina en la que se ha sustituido el dominio receptor de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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