{"id":41720,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/indentificacion-y-caracterizacion-funcional-del-antigeno-pa226-asociado-a-la-carcinogenesis-quimica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"indentificacion-y-caracterizacion-funcional-del-antigeno-pa226-asociado-a-la-carcinogenesis-quimica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/indentificacion-y-caracterizacion-funcional-del-antigeno-pa226-asociado-a-la-carcinogenesis-quimica\/","title":{"rendered":"Indentificacion y caracterizacion funcional del antigeno pa226 asociado a la carcinogenesis quimica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Manuel Gomez Scholl <\/strong><\/h2>\n<p>El anticuerpo monoclonal pa2,26, generado contra una l\u00ednea de queratinocitos transformados, reconoce a una prote\u00edna de la membrana plasm\u00e1tica que se induce durante la carcinogenesis qu\u00edmica de piel de rat\u00f3n. El ant\u00edgeno pa2.26 est\u00e1 ausente de la piel normal, pero se expresa en l\u00edneas de carcinoma y en tumores inducidos quimicamente.  en este estudio de ha realizado la caracterizaci\u00f3n del ant\u00edgeno as\u00ed como el clonaje de su cdna. pa2.26 es una prote\u00edna transmembrana tipo mucina que se localiza en proyecciones de la membrana plasm\u00e1tica como microvillis, filopodios y lamellipodios, donde se asocia a los filamentos de actina a trav\u00e9s probablemente de los miembros de la familia de prote\u00ednas erm:ezrina y moesina.  la transfecci\u00f3n del cdna de pa2.26 en queratinocitos no tumorig\u00e9nicos, induce una conversi\u00f3n epitelial-fibroblastoide asociada a una reorganizaci\u00f3n del citoesqueleto de actina, que conduce a la p\u00e9rdida de uniones adherentes mediadas por los complejos cadherina\/catenina. Las c\u00e9lulas transfectadas con pa2.26 adquieren adem\u00e1s un fenotipo migratorio y tumoral.  estos resultados indican una implicaci\u00f3n funcional del ant\u00edgeno en la motilidad celular y en la carcinog\u00e9nesis..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Indentificacion y caracterizacion funcional del antigeno pa226 asociado a la carcinogenesis quimica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Indentificacion y caracterizacion funcional del antigeno pa226 asociado a la carcinogenesis quimica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Manuel Gomez Scholl <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Quintanilla Avila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>Luis Alvarez garcia (vocal)<\/li>\n<li>Francisco xavier Real arribas (vocal)<\/li>\n<li>angels Fabra fres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Manuel Gomez Scholl El anticuerpo monoclonal pa2,26, generado contra una l\u00ednea de queratinocitos transformados, reconoce a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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