{"id":41726,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-transporte-nuclear-de-las-proteinas-de-la-capsida-del-parvovirus-mvm-esta-regulado-por-el-ciclo-celular\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"el-transporte-nuclear-de-las-proteinas-de-la-capsida-del-parvovirus-mvm-esta-regulado-por-el-ciclo-celular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-transporte-nuclear-de-las-proteinas-de-la-capsida-del-parvovirus-mvm-esta-regulado-por-el-ciclo-celular\/","title":{"rendered":"El transporte nuclear de las proteinas de la capsida del parvovirus mvm esta regulado por el ciclo celular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Hernando Monge <\/strong><\/h2>\n<p>Los parvovirus son virus icosah\u00e9ricos con genomas dna que replican su genoma y maduran en el n\u00facleo de la c\u00e9lula. La infecci\u00f3n por parvovirus requiere funciones celulares expresadas transitoriamente durante la fase s del ciclo celular. Hemos analizado si la localizaci\u00f3n subcelular de las prote\u00ednas vp1 y vp2 de la c\u00e1psida del parvovirus mvm es ciclo celular dependiente.  en c\u00e9lulas a9 o 4k, permanentemente transfectadas con el gen vp de mvm, arrestadas por confluencia del cultivo (fase g1), las vps se sit\u00faan exclusivamente en el citoplasma.  resultados similares se han obtenido sincronizando mediante privaci\u00f3n de suero (go), o de isoleucina seguida de la adici\u00f3n de afidicolina (transici\u00f3n g1\/s). Sin embaergo, cuando las c\u00e9lulas se liberan del arresto, las prote\u00ednas vps se localizan progresivamente en el n\u00facleo de las c\u00e9lulas coincidiendo con la entrada en fase s (monitorizada por expresi\u00f3n de pcna). Adem\u00e1s el doble bloqueo con timidina retiene a las vps en el citoplasma, pese a la expresi\u00f3n y localizaci\u00f3n nuclear normal de pcna: por tanto, la traslocaci\u00f3n al n\u00facleo de las prote\u00ednas estructurales del mvm requiere la s\u00edntesis del adn celular: esta regulaci\u00f3n ciclo-dependiente del transporte es ejercida asimismo sobre el transporte de las prote\u00ednas sintetizadas de novo en la infecci\u00f3n por mvm.  vp1 y vp2 presentan requerimientos distintos para su transporte nuclear. Cuando se expresan por separado, vp2 pero no vp1 se transporta al n\u00facleo independientemente de la fase del ciclo celular. En coexpresi\u00f3n de ambas prote\u00ednas, la interacci\u00f3n con vp2 enmascara funcional y f\u00edsicamente, entre la nls de vp1, posiblemente, el transporte al n\u00facleo opera por cambios conformacionales que exponen la nls de vp2 y de vp1 para su interaci\u00f3n con la maquinaria de transporte.  el tipo de fosforilaci\u00f3n de vp2 no cambia significativamente a lo largo del ciclo, ni requiere la presencia de las prote\u00ednas no estruc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El transporte nuclear de las proteinas de la capsida del parvovirus mvm esta regulado por el ciclo celular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El transporte nuclear de las proteinas de la capsida del parvovirus mvm esta regulado por el ciclo celular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Hernando Monge <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Almendral Del Rio Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Carrasco llamas <\/li>\n<li>mauricio Garcia mateu (vocal)<\/li>\n<li>Juan Ortin martin (vocal)<\/li>\n<li>Manuel Serrano marug\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Hernando Monge Los parvovirus son virus icosah\u00e9ricos con genomas dna que replican su genoma y maduran [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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