{"id":41728,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-actividad-de-la-integrina-vla-4-por-la-quimioquina-sdf-la-en-progenitores-hematopoyeticos-relaciones-funcionales-de-vla-4-y-cd44-en-hematopoyesis\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"modulacion-de-la-actividad-de-la-integrina-vla-4-por-la-quimioquina-sdf-la-en-progenitores-hematopoyeticos-relaciones-funcionales-de-vla-4-y-cd44-en-hematopoyesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-de-la-actividad-de-la-integrina-vla-4-por-la-quimioquina-sdf-la-en-progenitores-hematopoyeticos-relaciones-funcionales-de-vla-4-y-cd44-en-hematopoyesis\/","title":{"rendered":"Modulacion de la actividad de la integrina vla-4 por la quimioquina sdf-la en progenitores hematopoyeticos. relaciones funcionales de vla-4 y cd44 en hematopoyesis."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andres Hidalgo Alonso <\/strong><\/h2>\n<p>En esta tesis se ha estudiado la capacidad de la quimioquina sdf-la en la actividad de la integrina vla-4 expresada en c\u00e9lulas progenitores hematopoy\u00e9ticas, con el objeto de encontrar un mecanismo de interrelaci\u00f3n entre ambas mol\u00e9culas, dado el papel central de ambas en la hematopoyesis. sdf-la modula de manera r\u00e1pida y transitoria la adhesi\u00f3n a ligandos de vla-4 (fn-h89 y vcam-1), tanto en c\u00e9lulas progenitoras (l\u00edneas y c\u00e9lulas cd34+ de m\u00e9dula \u00f3sea) como c\u00e9lulas de mieloma m\u00faltiple que expresaban el receptor de sdf-1, cxcr4, en superficie. El incremento de adhesi\u00f3n inducido por la quimioquina depende de la se\u00f1alizaci\u00f3n a trav\u00e9s de prote\u00ednas g heterotrim\u00e9ricas asociadas al receptor y, en la adhesi\u00f3n a fn-h89, de un citoesqueleto de actina intacto.  adicionalmente, sdf-la modula tambi\u00e9n la actividad de las integrinas a4b7 y vla-5 en c\u00e9lulas hematopoy\u00e9ticas. Finalmente, sdf-la produce la activaci\u00f3n de las map quinasas y de pyk2 en c\u00e9lulas progenitoras hematopoy\u00e9ticas.  en la segunda parte de la tesis se han caracterizado dos anticuerpos monoclonales (acm) generados en el laboratorio que eran espec\u00edficos de cd44 de raton. Estos anticuerpos, junto con otro acm contra cd44 incrementan la adhesi\u00f3n de progenitores hematopoy\u00e9ticos a cbelulas estromales de m\u00e9dula \u00f3sea cuando las c\u00e9lulas progenitoras se preincuban con los acm antes de la adhesi\u00f3n.  este incremento de adhesi\u00f3n implica, al menos en parte, la activaci\u00f3n de la integrina vla-4 en las c\u00e9lulas progenitoras, ya que la preincubaci\u00f3n con el acm anti-cd44 ma-8, pero no con el acm im7.8.1, induce un incremento en la adehsi\u00f3n al ligando cs-1\/fn de vla-4 en estas c\u00e9lulas. Por \u00faltimo, el acm im7, pero no ma-8 contra cd44, inhibe considerablemente la hematopoyesis en cultivos a largo t\u00e9rmino tipo dexter e induce la liberaci\u00f3n de precursores cfu-gm al medio de cultivo. El acm anti-integrinas a4 retrasa la mielopoyesis en es<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulacion de la actividad de la integrina vla-4 por la quimioquina sdf-la en progenitores hematopoyeticos. relaciones funcionales de vla-4 y cd44 en hematopoyesis.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulacion de la actividad de la integrina vla-4 por la quimioquina sdf-la en progenitores hematopoyeticos. relaciones funcionales de vla-4 y cd44 en hematopoyesis. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andres Hidalgo Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Teixid\u00f3 Calvo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Sanchez Madrid <\/li>\n<li>angeles Garcia pardo (vocal)<\/li>\n<li>Miguel angel Rodriguez marcos (vocal)<\/li>\n<li>Mar\u00eda  Luisa Toribio garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andres Hidalgo Alonso En esta tesis se ha estudiado la capacidad de la quimioquina sdf-la en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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