{"id":41752,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-factor-tgf-beta1-induce-una-conversion-epitelial-fibroblastica-en-queratinocitos-transformados-de-epidermis-de-raton-implicaciones-en-la-progresion-maligna\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"el-factor-tgf-beta1-induce-una-conversion-epitelial-fibroblastica-en-queratinocitos-transformados-de-epidermis-de-raton-implicaciones-en-la-progresion-maligna","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/el-factor-tgf-beta1-induce-una-conversion-epitelial-fibroblastica-en-queratinocitos-transformados-de-epidermis-de-raton-implicaciones-en-la-progresion-maligna\/","title":{"rendered":"El factor tgf-beta1 induce una conversion epitelial-fibroblastica en queratinocitos transformados de epidermis de raton. implicaciones en la progresion maligna."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Frontelo Fernandez M. Pilar <\/strong><\/h2>\n<p>En este estudio se han analizado los efectos del factor tgf-beta1 en la proliferaci\u00f3n y diferenciaci\u00f3n de queratinocitos normales y transformados de piel de rat\u00f3n. El hallazgo principal de este estudio es que tgf-beta1 induce una conversi\u00f3n epitelial-fibrobl\u00e1stica (cef) en queratinocitos transformados de la l\u00ednea celular pdv, mientras que bloquea el crecimiento y promueve la muerte celular, probablemente por apoptosis, de queratinocitos inmortalizados no tumorog\u00e9nicos mca3d. Para que produzca la cef las c\u00e9lulas requieren una exposici\u00f3n prolongada de m\u00e1s de dos semanas al factor. Tgf-beta1 no modula directamente la expresi\u00f3n de genes de diferenciaci\u00f3n epitelial como cadherina e y queratinas. Sin embargo, durante la primera semana de tratamiento, tgf-beta1 induce la deslocalizaci\u00f3n de cadherina e y beta-catenina, la p\u00e9rdida de las unioneadherentes mediada por estas mol\u00e9culas, y estimula la migraci\u00f3n celular y la producci\u00f3n de proteasas de maztriz extracelular: uroquinasa y mmp-9. Estos efectos tempranos de tgf-beta1 (remodelaci\u00f3n de matriz extracelular y de citoesqueleto) podr\u00edan desencadenar la cef que ocurre posteriormente. En este trabajo se demuestra, asimismo, que la cef inducida por el factor en queratinocitos transformados en cultivo est\u00e1 asociada, \u00abin vivo\u00bb, a una transici\u00f3n hacia carcinomas indiferenciados m\u00e1s invasivos y malignos, y a la adquisici\u00f3n de un potencial metast\u00e1sico. los resultados presentados en esta tesis nos llevan a postular una funci\u00f3n dual de tgf-beta1 en la carcinog\u00e9nesis epid\u00e9rmica, como supresor tumoral dual de tgf-beta1 en la carcinog\u00e9nesis epid\u00e9rmica, como supresor tumoral en los primeros estad\u00edos de la carcinog\u00e9nesis, y como estimulador de la progresi\u00f3n maligna en las \u00faltimas etapas del desarrollo tumoral..<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El factor tgf-beta1 induce una conversion epitelial-fibroblastica en queratinocitos transformados de epidermis de raton. implicaciones en la progresion maligna.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El factor tgf-beta1 induce una conversion epitelial-fibroblastica en queratinocitos transformados de epidermis de raton. implicaciones en la progresion maligna. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Frontelo Fernandez M. Pilar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Quintanilla Avila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Le\u00f3n serrano <\/li>\n<li>carmelo Bernabeu quiante (vocal)<\/li>\n<li>Jaime Renart pita (vocal)<\/li>\n<li>Manuel Serrano marug\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Frontelo Fernandez M. Pilar En este estudio se han analizado los efectos del factor tgf-beta1 en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,115,17],"tags":[105528,105527,77558,14452,41977,7260],"class_list":["post-41752","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-bioquimica-molecular","category-quimica","tag-carmelo-bernabeu-quiante","tag-frontelo-fernandez-m-pilar","tag-jaime-renart-pita","tag-javier-leon-serrano","tag-manuel-serrano-marugan","tag-miguel-quintanilla-avila"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=41752"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/41752\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=41752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=41752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=41752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}