{"id":42048,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilidad-pronostica-del-analisis-cuantitativo-de-la-oncoproteina-p185her-2-neu-en-el-cancer-de-mama-con-ganglios-positivos\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"utilidad-pronostica-del-analisis-cuantitativo-de-la-oncoproteina-p185her-2-neu-en-el-cancer-de-mama-con-ganglios-positivos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilidad-pronostica-del-analisis-cuantitativo-de-la-oncoproteina-p185her-2-neu-en-el-cancer-de-mama-con-ganglios-positivos\/","title":{"rendered":"Utilidad pronostica del analisis cuantitativo de la oncoproteina p185her-2\/neu en el cancer de mama con ganglios positivos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Uriel Bohn Sarmiento <\/strong><\/h2>\n<p>El oncog\u00e9n her2\/neu (tambi\u00e9n llamado erbb2) codifica para una glucoprote\u00edna transmembranal de 185 kda(p185), que es un receptor de factor de crecimiento con actividad tirosina quinasa intracelular. En humanos la amplificaci\u00f3n g\u00e9nica (n\u00famero extra de copias) del her-2 conduce a la sobreexpresi\u00f3n de la p185. la sobreexpresi\u00f3n de la oncoprote\u00edna facilita la formaci\u00f3n de homod\u00edmeros y de heterod\u00edmeros con otros miembros de la familia de receptores con actividad tirosina quinasa tipo i (receptor del factor de crecimiento epid\u00e9rmico (egfr) y hom\u00f3logos (her3 y her4), la autofosforilaci\u00f3n del receptor y la subsecuente activaci\u00f3n de sustratos con actividad quinasa envueltos en los mecanismos de transducci\u00f3n de se\u00f1ales, y que eventualmente afectar\u00e1n la transcripci\u00f3n de genes que regulan la progresi\u00f3n de ciclo celular.  en el c\u00e1ncer de mama se ha descrito que entre un 5 y un 40% de los tumores de una serie presentan el oncog\u00e9n her2 amplificado y\/o la p185 sobreexpresada.  la sobreexpresi\u00f3n del oncogen her2 (llamado tambi\u00e9n erbb2 o neu) juega un papel significativo en la patog\u00e9nesis del c\u00e1ncer de mama, y es un suceso que es considerado comunmente como un indicador de mar pron\u00f3stico. la sobreexpresi\u00f3n del her2 ha sido tambi\u00e9n asociada a sensibilidad y\/o resistencia a la terapia hormonal y a reg\u00edmenes quimioterap\u00e9uticos, incluyendo cmf (ciclofosfamida, metotrexato y fluouracilo) y antraciclinas.  la mayor\u00eda de los estudios sobre la expresi\u00f3n de este oncog\u00e9n se han realizado mediante procedimientos cualitativos o semicuantitativos, tales como inmunohistoqu\u00edmicas y western blot.  en este trabajo hemos analizado cuantitativamente la p185 mediante un procedimiento tipo elisa y estudiado su posible utilidad pron\u00f3stica en 217 pacientes con c\u00e1ncer de mama con g\u00e1nglios positivos.  las caracter\u00edsticas de las pacientes de la serie se correspond\u00edan con las de la mayor\u00eda de las series en las que los tum<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilidad pronostica del analisis cuantitativo de la oncoproteina p185her-2\/neu en el cancer de mama con ganglios positivos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilidad pronostica del analisis cuantitativo de la oncoproteina p185her-2\/neu en el cancer de mama con ganglios positivos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Uriel Bohn Sarmiento <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Diaz Chico Juan  Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: bonifacio nicol\u00e1s Diaz chico <\/li>\n<li>leandro Fernandez perez (vocal)<\/li>\n<li> Vega benitez victor m. (vocal)<\/li>\n<li>norberto Batista lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Uriel Bohn Sarmiento El oncog\u00e9n her2\/neu (tambi\u00e9n llamado erbb2) codifica para una glucoprote\u00edna transmembranal de 185 kda(p185), [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,160,115,155,35,9,347,16629,3178,17],"tags":[16660,16677,16663,10140,106061,106062],"class_list":["post-42048","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-bioquimica","category-bioquimica-molecular","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-oncologia-clinica","category-palmas-de-gran-canaria","category-proteinas","category-quimica","tag-bonifacio-nicolas-diaz-chico","tag-diaz-chico-juan-carlos","tag-leandro-fernandez-perez","tag-norberto-batista-lopez","tag-uriel-bohn-sarmiento","tag-vega-benitez-victor-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42048"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42048\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}