{"id":42052,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-experimental-del-efecto-de-los-antioxidantes-desferroxamina-y-u-74389g-sobre-la-lesion-por-isquemia-reperfusion-hepatica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-experimental-del-efecto-de-los-antioxidantes-desferroxamina-y-u-74389g-sobre-la-lesion-por-isquemia-reperfusion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-experimental-del-efecto-de-los-antioxidantes-desferroxamina-y-u-74389g-sobre-la-lesion-por-isquemia-reperfusion-hepatica\/","title":{"rendered":"Estudio experimental del efecto de los antioxidantes desferroxamina y u-74389g sobre la lesion por isquemia-reperfusion hepatica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramon Agustin Dominguez Diez <\/strong><\/h2>\n<p>Se ha analizado un modelo experimental en el que se producen los fen\u00f3menos isqu\u00e9micos y reperfusivos a los que se somete el h\u00edgado en diversas circustancias.  para ello se crearon 8 grupos de 8 animales cada uno (ratas sprague-dawley). El primero fue el grupo control en el que s\u00f3lo se realiz\u00f3 una laparotom\u00eda media y una manipulaci\u00f3n del h\u00edgado. En todos los dem\u00e1s se llev\u00f3 a cabo una isquemia segmentaria del h\u00edgado (aproximadamente un 70% del par\u00e9nquima total) mediante el clampaje de los elementos vasculares y biliares de los l\u00f3bulos medial y lateral izquierdo durante 75 minutos. Posteriormente se reperfundi\u00f3 el \u00f3rgano durante 1 hora (grupos iii, v, vii) o 24 horas (grupos iv, vi, viii) permitiendo que sucedieran por tanto la cascada de acontecimientos que acompa\u00f1a a la reperfusi\u00f3n. en los grupos v y vi se administr\u00f3 desferroxamina 30 minutos antes de la isquemia, mientras que en los grupos vii y viii se utiliz\u00f3 u-74389g, un aminoesteroide de nueva generaci\u00f3n, 30 minutos antes de la isquemia y justo antes de la reperfusi\u00f3n.  una vez concluido, se procedi\u00f3 a la extracci\u00f3n de muestras de sangre y del h\u00edgado afectado para proceder a la medici\u00f3n de enzimas hep\u00e1ticas (alt y ast), ldh, bilirrubina total, malonidialdehido, 4-hidroxinonenal y glutation en suero y malonidialdehido, 4-hidroxinonenal y glutation en tejido hep\u00e1tico. Se realiz\u00f3 adem\u00e1s el estudio histol\u00f3gico de las muestras de h\u00edgado utilizando dos tinciones, hematoxilina-eosina y pas. Con todo ello se compar\u00f3 el efecto de estas dos sustancias sobre los fen\u00f3menos de isquemia-reperfusi\u00f3n, fundamentalmente en relaci\u00f3n con los radicales libres y la peroxidaci\u00f3n lip\u00eddica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio experimental del efecto de los antioxidantes desferroxamina y u-74389g sobre la lesion por isquemia-reperfusion hepatica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio experimental del efecto de los antioxidantes desferroxamina y u-74389g sobre la lesion por isquemia-reperfusion hepatica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramon Agustin Dominguez Diez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Ram\u00f3n Hern\u00e1ndez Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Rodr\u00edguez montes <\/li>\n<li>Jos\u00e9 Regidor Garc\u00eda (vocal)<\/li>\n<li>Manuel Gomez fleitas (vocal)<\/li>\n<li> Hernandez romero Juan  m. (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramon Agustin Dominguez Diez Se ha analizado un modelo experimental en el que se producen los fen\u00f3menos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,16629],"tags":[106071,3775,10224,16700,10508,106070],"class_list":["post-42052","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-palmas-de-gran-canaria","tag-hernandez-romero-juan-m","tag-jose-antonio-rodriguez-montes","tag-jose-regidor-garcia","tag-juan-ramon-hernandez-hernandez","tag-manuel-gomez-fleitas","tag-ramon-agustin-dominguez-diez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42052"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42052\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}