{"id":42177,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-clinico-y-experimental-de-actividades-mitogenicas-y-no-mitogenicas-del-factor-de-crecimientopara-fibroblastos-fgf-en-el-sistema-cardiovascular\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-clinico-y-experimental-de-actividades-mitogenicas-y-no-mitogenicas-del-factor-de-crecimientopara-fibroblastos-fgf-en-el-sistema-cardiovascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-clinico-y-experimental-de-actividades-mitogenicas-y-no-mitogenicas-del-factor-de-crecimientopara-fibroblastos-fgf-en-el-sistema-cardiovascular\/","title":{"rendered":"Estudio clinico y experimental de actividades mitogenicas y no mitogenicas del factor de crecimientopara fibroblastos (fgf) en el sistema cardiovascular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vivencio Barrios Alonso <\/strong><\/h2>\n<p>En esta tesis doctoral se estudian diferentes actividades del factor de crecimiento para fibroblatos \u00e1cido (afgf) y b\u00e1sico (bfgf), en el sistema cardiovascular. para ello se incluyen dos estudios, uno cl\u00ednico y otro experimental.  en el estudio cl\u00ednico se analizaron los valores s\u00e9ricos de bfgf en 20 pacientes ingresados en la u. Coronaria del hospital ram\u00f3n y cajal con el diagn\u00f3stico de infarto agudo de miocardio (iam). Se realizaron determinaciones de bfgf en tres momentos: al ingreso, a los 10 d\u00edas y al mes. Se compararon los resultados con los de un grupo control de sujetos sanos. Al ingreso las cifras de bfgf fueron similares al grupo control, a los 10 d\u00edas se duplicaron, y al mes volvieron a su valor basal. Los iam anteriores presentaron cifras de bfgf a los 10 d\u00edas mayores que los iam de otras localizaciones. No se demostr\u00f3 relaci\u00f3n entre los niveles de bfgf y los diferentes factores de riesgo, valor m\u00e1ximo de cpk, funci\u00f3n ventricular ni datos de orgometr\u00eda. Esta elevaci\u00f3n transitoria de bfgf parece estar en relaci\u00f3n con la actividad angiog\u00e9nica del fgf y el desarrollo de circulaci\u00f3n colateral tras iam, como apuntan varias evidencias experimentales.  el estudio experimental se enfoc\u00f3 a actividades no mitog\u00e9nicas del fgf, se analiz\u00f3 el efecto vasomotor de afgf en el \u00e1rbol coronario del cerdo. Para dilucidar si el efecto vasomotor estaba ligado a no a la actividad mitog\u00e9nica, se estudi\u00f3 una forma no mitog\u00e9nica de afgf (nm-afgf). Se demostr\u00f3 que en arterias coronarias precontra\u00eddas con pgf 2 alfa un bolo intracoronario (i.C.) De afgf (60 g) provoc\u00f3 una intensa vasodilataci\u00f3n. el nm-afgf tambi\u00e9n fue un potente vasodilatador coronario, por lo que la actividad vasomotora no parece estar relacionada con la capacidad mitog\u00e9nica. La presi\u00f3n arterial media no se modific\u00f3 con afgf ni con nm-fgf i.C.#<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio clinico y experimental de actividades mitogenicas y no mitogenicas del factor de crecimientopara fibroblastos (fgf) en el sistema cardiovascular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio clinico y experimental de actividades mitogenicas y no mitogenicas del factor de crecimientopara fibroblastos (fgf) en el sistema cardiovascular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vivencio Barrios Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Cuevas S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>Santiago De pascual marcos (vocal)<\/li>\n<li> Ruilope urioste Luis Miguel (vocal)<\/li>\n<li>Manuel Luque otero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vivencio Barrios Alonso En esta tesis doctoral se estudian diferentes actividades del factor de crecimiento para fibroblatos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,932,9,139],"tags":[3111,14431,17690,39035,15368,106274],"class_list":["post-42177","post","type-post","status-publish","format-standard","hentry","category-alcala","category-cardiologia","category-ciencias-medicas","category-medicina-interna","tag-manuel-luque-otero","tag-melchor-alvarez-de-mon-soto","tag-pedro-cuevas-sanchez","tag-ruilope-urioste-luis-miguel","tag-santiago-de-pascual-marcos","tag-vivencio-barrios-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42177"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42177\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}