{"id":42178,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/correlatos-neuroquimicos-en-dolor-cronico-estudio-clinico-y-experimental-en-el-liquido-cefalorraquideo\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"correlatos-neuroquimicos-en-dolor-cronico-estudio-clinico-y-experimental-en-el-liquido-cefalorraquideo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/correlatos-neuroquimicos-en-dolor-cronico-estudio-clinico-y-experimental-en-el-liquido-cefalorraquideo\/","title":{"rendered":"Correlatos neuroquimicos en dolor cronico: estudio clinico y experimental en el liquido cefalorraquideo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Luis De La Calle Reviriego <\/strong><\/h2>\n<p>Los objetivos del trabajo consisten en buscar correlaciones de los niveles de amino\u00e1cidos y metabolitos de monoaminas en el l\u00edquido cefalorraqu\u00eddeo (lcr) con el desarrollo y el mantenimiento de dolor cr\u00f3nico. Con este fin se analizaron las concentraciones de dichas mol\u00e9culas en pacientes con dolor cr\u00f3nico intratable establecido y en animales a los que se hab\u00eda provocado dolor neurop\u00e1tico cr\u00f3nico de forma experimental.  el trabajo tambi\u00e9n incluye el estudio de los cambios en el perfil neuroqu\u00edmico del lcr y del comportamiento animal inducidos mediante el trasplante subaracnoideo de c\u00e9lulas monoamin\u00e9rgicas. Los resultados de dichos experimentos demuestran que los pacientes con dolor cr\u00f3nico intratable tienen un perfil neuroqu\u00edmico en el lcr diferente al de la poblaci\u00f3n control y que los cambios afectan tanto a los niveles de amino\u00e1cidos como a los de los metabolitos de las nomoaminas. Los resultados sugieren la posibilidad de establecer un patr\u00f3n neuroqu\u00edmico espec\u00edfico para el paciente con dolor cr\u00f3nico intratable y que dicho patr\u00f3n podr\u00eda ser diferente en funci\u00f3n de la etiolog\u00eda del cuadro cl\u00ednico subyacente. Otras variables que concurren en los pacientes con dolor cr\u00f3nico tambi\u00e9n influyen en los niveles de estas mol\u00e9culas, y espec\u00edficamente el trabajo ha puesto de manifiesto la relevancia de la variable \u00abrespuesta congruente al test de infusi\u00f3n\u00bb para los niveles de glutamato. En el modelo experimental que reproduce el dolor cr\u00f3nico, y mediante t\u00e9cnicas de obtenci\u00f3n del lcr similares a las que se utilizan en la cl\u00ednica, se observa que los niveles de amino\u00e1cidos y metabolitos de monoaminas presentan variaciones en las fases iniciales del desarrollo del dolor cr\u00f3nico, que son diferentes a las observadas cuando el dolor est\u00e1 ya establecido. Finalmente se comprueba que el trasplante de c\u00e9lulas productoras de monoaminas en animales con dolor cr\u00f3nico, modifica el perfil neuroqu\u00edmico del lcr y pr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Correlatos neuroquimicos en dolor cronico: estudio clinico y experimental en el liquido cefalorraquideo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Correlatos neuroquimicos en dolor cronico: estudio clinico y experimental en el liquido cefalorraquideo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Luis De La Calle Reviriego <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Paino Belarrinaga Carlos Luis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Lopez timoneda <\/li>\n<li>Rafael Mart\u00edn del r\u00edo (vocal)<\/li>\n<li> Madrid arias Jos\u00e9 Luis (vocal)<\/li>\n<li>maximino Lozano suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Luis De La Calle Reviriego Los objetivos del trabajo consisten en buscar correlaciones de los niveles [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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