{"id":42182,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-patogenicas-de-las-citocinas-en-la-enfermedad-de-paget\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"implicaciones-patogenicas-de-las-citocinas-en-la-enfermedad-de-paget","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-patogenicas-de-las-citocinas-en-la-enfermedad-de-paget\/","title":{"rendered":"Implicaciones patogenicas de las citocinas en la enfermedad de paget."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas M. Corres Gonzalez <\/strong><\/h2>\n<p>La enfermedad \u00f3sea de paget (ep) se caracteriza por una alteraci\u00f3n en el remodelado \u00f3seo basada en una intensa activaci\u00f3n de los osteoclastos (oc) y de la resorci\u00f3n \u00f3sea. Diversas citocinas proinflamatorias han mostrado sucapacidad en estudios \u00abin vivo\u00bb e \u00abin vitro\u00bb para activar a los oc, pero desconocemos su papel patog\u00e9nico en la ep. Del mismo modo, se han detectado algunas anomal\u00edas en la producci\u00f3n de il-1 por los monocitos de sangre perif\u00e9rica en sujetos con ep, sin haber sido estudiada la producci\u00f3n de otras citocinas, como la il-6 por \u00e9stas c\u00e9lulas. Determinamos en 62 pacientes con ep (36 hombres\/mujeres: edad media 65,74+- 11,02 a\u00f1os) y en 23 controles (10 hombres\/13 mujeres: edad media 67,8+-6,6) las concentraciones s\u00e9ricas de il-1 beta, il-6 y tnf-alfa mediante tres elisas comerciales. De los 62 pacientes con ep. 32 recibieron distintos tratamientos antirresortivos: 5 con pamidronato 15 mgrs\/24 h i.V. durante 5 d\u00edas, 4 con clodronato 400 mgr\/24 h v.O. Durante 3 meses, 17 con tiludronato 400 mgrs\/24 v.O. Durante 3 meses y 5 con calcitonina (10) unidades\/24 h s.C. en dos casos y 200 ui\/24 h inhaladas en 3 casos durante 3 meses. En estos pacientes se determin\u00f3 las concentraciones s\u00e9ricas de forma basal y a los 3 meses de iniciado el tratamiento. En otro estudio diferente estudiamos la producci\u00f3n de i1-6 en 16 pacientes con ep y 15 controles en cultivos de monocitos de sangre perif\u00e9rica aislados mediante gradiente de ficoll y ajustadas las c\u00e9lulas a 1 x 10 elevado a 6\/ml e incubadas durante 24 horas. La concentraci\u00f3n s\u00e9rica de il-6 en los pacientes con ep mostr\u00f3 un incrementos significativo respecto a los controles (19,45+-8,24 vs 10,74+-1,82 pg\/ml, p 0,001), no existiendo diferencias en las concentraciones de il-1 beta ni de tnf-alfa. La concentraci\u00f3n de il-6 se relacion\u00f3 en la ep con la extensi\u00f3n radiol\u00f3gica de la enfermedad determinada mediante el \u00edndice de coutris (r:0,32, p:0,003) y con los p<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones patogenicas de las citocinas en la enfermedad de paget.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones patogenicas de las citocinas en la enfermedad de paget. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas M. Corres Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Melchor Alvarez De Mon Soto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Rodriguez zapata <\/li>\n<li> Garcia de vicu\u00f1a rosario (vocal)<\/li>\n<li>ignacio Arribas g\u00f3mez (vocal)<\/li>\n<li>cristina Alvarez escola (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas M. Corres Gonzalez La enfermedad \u00f3sea de paget (ep) se caracteriza por una alteraci\u00f3n en el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9,139,877],"tags":[89223,106284,22956,106283,17588,14431],"class_list":["post-42182","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-medicas","category-medicina-interna","category-reumatologia","tag-cristina-alvarez-escola","tag-garcia-de-vicuna-rosario","tag-ignacio-arribas-gomez","tag-jesus-m-corres-gonzalez","tag-manuel-rodriguez-zapata","tag-melchor-alvarez-de-mon-soto"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42182"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42182\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}