{"id":4223,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/prediccion-de-la-dosis-eficaz-individual-de-clomipramina-aspectos-farmacologicos-y-clinicos\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"prediccion-de-la-dosis-eficaz-individual-de-clomipramina-aspectos-farmacologicos-y-clinicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/prediccion-de-la-dosis-eficaz-individual-de-clomipramina-aspectos-farmacologicos-y-clinicos\/","title":{"rendered":"Prediccion de la dosis eficaz individual de clomipramina. aspectos farmacologicos y clinicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda no Bet\u00e9s Del Toro <\/strong><\/h2>\n<p>Un elevado porcentaje de pacientes con depresion mayor (alrededor de un 30%) no suele responder satisfactoriamente al tratamiento la posible participacion farmacocinetica en este fenomeno, se ha comparado, mediante un ensayo clinico controlado doble ciego, la evoluciuon clinica de un grupo de pacientes tratados por una dosis adaptada de clomipramina (cmi) frente a un grupo control tratado con una posolog\u00eda habitual (150 mg\/dia). Ambos grupos fueron homogeneos respecto a edad, sexo, naturaleza y gravedad de la sintomatolog\u00eda depresiva. La dosis adaptada se calculo a partir de la curva de eliminacion de niveles plasmaticos de clomipramina, obtenida a lo largo de las 24 horas siguientes a la primera dosis del antidepresivo.  se observo una mejoria clinica significativamente mas rapida y completa de los sintomas depresivos en el grupo de posolog\u00eda ajustada farmacocineticamente (grupo prediccion), segun las escalas hdrs y madrs. El periodo de hospitalizacion de los enfermos \u00abprediccion\u00bb fue inferior (en 4,3 dias\/pacientes) al del grupo control.  despues de tres semanas de tratamiento con cmi, se ha detectado una relacion curvilinea entre concentraciones plasmaticas de clomipramina y mejoria clinica de la depresion, con un rango terapeutico para la cmi entre 100-200 ng\/ml. Dentro de este grupo, la mejor respuesta antidepresiva aparece con concentraciones plasmaticas de desmetilclomipramina (dcmi), dos a tres veces superiores a las del medicamento. Estos niveles plasmaticos son especialmente aplicables a episodios depresivos mayores.  la aplicacion de este metodo de prediccion farmacocinetica en los servicios de psiquiatria, puede suponer una mejora de la calidad de vida de los pacientes y un ahorro economico considerable, debido a la reduccion del tiempo de hospitalizacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Prediccion de la dosis eficaz individual de clomipramina. aspectos farmacologicos y clinicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Prediccion de la dosis eficaz individual de clomipramina. aspectos farmacologicos y clinicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda no Bet\u00e9s Del Toro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduardo Cuenca Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Cecilio \u00e1lamo Gonz\u00e1lez <\/li>\n<li>Luis Lafuente Nu\u00f1ez (vocal)<\/li>\n<li>Jos\u00e9 Luis Bardasano Rubio (vocal)<\/li>\n<li>Jos\u00e9 Luis Ayuso Gutierrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda no Bet\u00e9s Del Toro Un elevado porcentaje de pacientes con depresion mayor (alrededor de un 30%) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,9,957],"tags":[17488,289,1846,17459,1729,899],"class_list":["post-4223","post","type-post","status-publish","format-standard","hentry","category-alcala","category-ciencias-medicas","category-farmacologia","tag-cecilio-alamo-gonzalez","tag-eduardo-cuenca-fernandez","tag-jose-luis-ayuso-gutierrez","tag-jose-luis-bardasano-rubio","tag-luis-lafuente-nunez","tag-maria-no-betes-del-toro"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/4223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=4223"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/4223\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=4223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=4223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=4223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}