{"id":42244,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/infeccion-estafilococica-asociada-a-la-formacion-de-biofilms-tratamiento-antibiotico-y-otras-opciones-terapeuticas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"infeccion-estafilococica-asociada-a-la-formacion-de-biofilms-tratamiento-antibiotico-y-otras-opciones-terapeuticas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/infeccion-estafilococica-asociada-a-la-formacion-de-biofilms-tratamiento-antibiotico-y-otras-opciones-terapeuticas\/","title":{"rendered":"Infeccion estafilococica asociada a la formacion de biofilms: tratamiento antibiotico y otras opciones terapeuticas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Monzon Garces <\/strong><\/h2>\n<p>Se desarroll\u00f3 un test de antibi\u00f3ticos para s. epidermidis en biofilm basado en la t\u00e9cnica de atp-bioluminiscencia para cuantificar las bacterias viables en el interior de dichos biofilms. Con \u00e9l se determin\u00f3 el efecto in vitro de 9 antimicrobianos, utilizando 4 cepas productoras de slime (sp). tetraciclina y rifampicina alcanzaron la mayor eficacia. el test se aplic\u00f3 tambi\u00e9n al estudio del efecto de 9 combinaciones de antibi\u00f3ticos; aqu\u00e9llas que inclu\u00edan tetraciclina junto con clindamicina, rifampicina y vancomicna resultaron las m\u00e1s eficaces. Se evidenci\u00f3 un efecto sin\u00e9rgico en todas las combinaciones testadas. Para determinar la correlaci\u00f3n entre los resultados in vivo e in vitro, se desarrollaron 4 modelos de osteomielitis cr\u00f3nica en rata (usando una cepa sp de s. Aureus). Solamente el modelo basado en un implante precolonizado alcanz\u00f3 un 100% de \u00e9xito en la infecci\u00f3n. Se determin\u00f3 el efecto de los tratamientos con cefuroxima, vancomicina, tobramicina y ciprofloxacino aplicados sobre este modelo. Los resultados obtenidos in vivo coincid\u00edan con los obtenidos in vitro, por lo que qued\u00f3 validado el test in vitro para biofilms. Se realiz\u00f3 un estudio sobre el efecto bactericida de las ondas de choque sobre biofilms estafiloc\u00f3cicos. El tratamiento con un nivel de energ\u00eda medio alcanz\u00f3 los mejores resultados. Se inici\u00f3, para mejorar el diagn\u00f3stico de la infecci\u00f3n por s. Aureus, un estudio en leche bovina. Las colonias con morfolog\u00eda rugosa en cra correspond\u00edan siempre a animales cr\u00f3nicos. Para determinar la presencia de anticuerpos s\u00e9ricos frente estafilococos en estos animales, se desarroll\u00f3 un elisa usando como ant\u00edgeno el extracto crudo de una cepa sp de s. aureus. Se observ\u00f3 un solapamiento de las distribuciones en el elisa entre categor\u00edas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Infeccion estafilococica asociada a la formacion de biofilms: tratamiento antibiotico y otras opciones terapeuticas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Infeccion estafilococica asociada a la formacion de biofilms: tratamiento antibiotico y otras opciones terapeuticas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Monzon Garces <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Beatriz Amorena Zabalza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: carmen Rota garcia <\/li>\n<li>i\u00f1igo Lasa uzcudun (vocal)<\/li>\n<li>Francisco Forriol campos (vocal)<\/li>\n<li>ignacio Moriyon uria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Monzon Garces Se desarroll\u00f3 un test de antibi\u00f3ticos para s. epidermidis en biofilm basado en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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