{"id":42248,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inmunoterapia-de-los-tumores-hepaticos-empleando-retrovirus-que-expresan-b7-1-y-o-il-12\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"inmunoterapia-de-los-tumores-hepaticos-empleando-retrovirus-que-expresan-b7-1-y-o-il-12","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/inmunoterapia-de-los-tumores-hepaticos-empleando-retrovirus-que-expresan-b7-1-y-o-il-12\/","title":{"rendered":"Inmunoterapia de los tumores hepaticos empleando retrovirus que expresan b7-1 y\/o il-12."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Yonglian Sun <\/strong><\/h2>\n<p>Con el f\u00edn de investigar el efecto antitumoral de c\u00e9lulas tumorales ingenierizadas para expresar los genes b7-1 y\/o il-12 en un modelo murino de hepatocarcinoma, desarrollamos vectores retrovirales que expresan el gen humano b7-1 (hb7-1), el gen murino de la citokina il-12 (mil-12) o ambos de forma coordinada. Para \u00e9ste f\u00edn c\u00e9lulas bnl murinas fueron modificadas para expresar de forma estable b7-1, mil-12 o ambos genes mediante la infecci\u00f3n con los respectivos retrovirus. Nuestros resultados muestran que tras la administraci\u00f3n de c\u00e9lulas bnl que expresan b7-1, il-12 o ambos genes no se observ\u00f3 desarrollo tumoral en el 20, 75 y 95% respectivamente, incluso 250 d\u00edas despu\u00e9s de la inoculaci\u00f3n. contrariamente la inyecci\u00f3n de c\u00e9lulas bnl no modificadas o que expresan el gen de la neomicina (bnl\/neo), como control, indujo el desarrollo letal de tumores en todos los animales. Se observ\u00f3 inmunidad protectiva ante una nueva inoculaci\u00f3n con c\u00e9lulas tumorales s\u00f3lamente en los animales que hab\u00edan rechazado previamente a las c\u00e9lulas bnl\/il-12, no dect\u00e1ndose este efecto en el caso de los animales que hab\u00edan recibido bnl\/b7-1 o bnl\/b7-1-il-12. El crecimiento de las c\u00e9lulas de hepatocarcinoma se retras\u00f3 significativamente cuando se realiz\u00f3 la inyecci\u00f3n simult\u00e1nea, en sitios distantes, de c\u00e9lulas tumorales irradiadas y que expresaban il-12 o b7-1\/il-12, pero no se observ\u00f3 el mismo efecto empleando c\u00e9lulas que expresaban b7-1 solamente. El tratamiento de tumores establecidos mediante la inyecci\u00f3n intratumoral directa de c\u00e9lulas empaquetadoras de retrovirus que expresan el gen de la il-12 o il-12\/b7-1 resulta en una significativa inhibici\u00f3n del crecimiento de los tumores y en un incremento en la supervivencia que fue similar en ambos grupos. La inmunidad antitumoral inducida por b7-1 depende exclusivamente de las c\u00e9lulas t cd4+, la terapia que combina la administraci\u00f3n de b7-1 e il-12 depende en gran medida de las<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inmunoterapia de los tumores hepaticos empleando retrovirus que expresan b7-1 y\/o il-12.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inmunoterapia de los tumores hepaticos empleando retrovirus que expresan b7-1 y\/o il-12. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Yonglian Sun <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas M. Prieto Valtue\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joan ignasi Esteban mur <\/li>\n<li> Idoate gastearena Miguel angel (vocal)<\/li>\n<li>Fernando Vidal vanaclocha (vocal)<\/li>\n<li>Juan Ruiz echevarria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Yonglian Sun Con el f\u00edn de investigar el efecto antitumoral de c\u00e9lulas tumorales ingenierizadas para expresar los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,9399,4667,1737,17749,6956,280],"tags":[12983,46944,15059,13798,41355,106384],"class_list":["post-42248","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-cultivo-celular","category-inmunizacion","category-inmunologia","category-navarra","category-retrovirus","category-virologia","tag-fernando-vidal-vanaclocha","tag-idoate-gastearena-miguel-angel","tag-jesus-m-prieto-valtuena","tag-joan-ignasi-esteban-mur","tag-juan-ruiz-echevarria","tag-yonglian-sun"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42248"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42248\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}