{"id":42252,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/dano-hepatico-producido-por-la-droga-de-abuso-extasis-mdma-a-corto-y-largo-plazo\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"dano-hepatico-producido-por-la-droga-de-abuso-extasis-mdma-a-corto-y-largo-plazo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/dano-hepatico-producido-por-la-droga-de-abuso-extasis-mdma-a-corto-y-largo-plazo\/","title":{"rendered":"Da\u00f1o hepatico producido por la droga de abuso extasis (mdma) a corto y largo plazo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guadalupe Beitia Berrotaran <\/strong><\/h2>\n<p>El n\u00famero de casos de presunta hepatoxicidad atribuida o relacionada con el uso de \u00ab\u00e9xtasis\u00bb ha aumentado considerablemente en los \u00faltimos a\u00f1os. Este estudio tiene por objeto establecer el efecto de la droga tras la administraci\u00f3n \u00fanica o repetida a corto y largo plazo sobre par\u00e1metros indicativos de toxicidad hep\u00e1tica y esclarecer el mecanismo por el cual la mdma induce la hepatotoxicidad. En primer lugar se realiz\u00f3 un estudio in vitro en suspensiones y cultivos primarios de hepatocitos aislados de rata. Posteriormente se realiz\u00f3 un estudio in vivo en el que se valor\u00f3 el efecto de la administraci\u00f3n \u00fanica y repetida de mdma. La mdma (0,1-5 mm) indujo un incremento tiempo y concentraci\u00f3n dependiente en las actividades enzim\u00e1ticas alt ast y ldh; produjo un r\u00e1pido incremento concentraci\u00f3n dependiente de los niveles citos\u00f3licos de calcio y una significativa disminuci\u00f3n tiempo y concentraci\u00f3n dependiente del contenido celular de glutation reducido (gsh) y de los niveles celulares de atp. La mdma produjo un incremento de los niveles del rnam de procol\u00e1geno alfa 1 (i) a trav\u00e9s de un mecanismo dependiente de la depleci\u00f3n de gsh y de la producci\u00f3n de per\u00f3xido de hidr\u00f3geno en una l\u00ednea de c\u00e9lulas estelares hep\u00e1ticas cirr\u00f3ticas. La inhibici\u00f3n del efecto profibrog\u00e9nico por desferroxiamina, ester de glutation y catalasa sugiere la mediaci\u00f3n de estr\u00e9s oxidativo en el incremento de los niveles de rnam de procol\u00e1geno alfa 1(i) inducido por la mdma. La administraci\u00f3n de una dosis de mdma (20 mg\/kg, i.P.) Tres horas antes del sacrificio, provoc\u00f3 un importante descenso del contenido hep\u00e1tico de gluc\u00f3geno. la administraci\u00f3n de una dosis de mdma, seis horas antes del sacrificio provoc\u00f3 un aumento significativo de la actividad s\u00e9rica transaminasa (alt, ast) y fosfatasa alcalina. Tambi\u00e9n se apreci\u00f3 una acumulaci\u00f3n grasa hep\u00e1tica caracterizada por el incremento de triglic\u00e9ridos y colesterol y una depleci\u00f3n si<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Da\u00f1o hepatico producido por la droga de abuso extasis (mdma) a corto y largo plazo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Da\u00f1o hepatico producido por la droga de abuso extasis (mdma) a corto y largo plazo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guadalupe Beitia Berrotaran <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Edurne Cenarruzabeitia Sagarminaga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Zaragoza garcia <\/li>\n<li>berta esperanza Lasheras aldaz (vocal)<\/li>\n<li>Jos\u00e9 Mar\u00eda Calleja suarez (vocal)<\/li>\n<li>Mar\u00eda Jos\u00e9 Iraburu elizalde (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guadalupe Beitia Berrotaran El n\u00famero de casos de presunta hepatoxicidad atribuida o relacionada con el uso de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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