{"id":42253,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":""},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efectos-en-la-utilizacion-energetica-y-en-la-expresion-del-gen-de-la-obesidad-y-proteinas-desacoplantes-ucp1-y-ucp2-de-un-nuevo-agonista-adrenergico-beta3-en-un-modelo-de-obesidad-inducido-con-una-d","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-en-la-utilizacion-energetica-y-en-la-expresion-del-gen-de-la-obesidad-y-proteinas-desacoplantes-ucp1-y-ucp2-de-un-nuevo-agonista-adrenergico-beta3-en-un-modelo-de-obesidad-inducido-con-una-d\/","title":{"rendered":"Efectos en la utilizacion energetica y en la expresion del gen de la obesidad y proteinas desacoplantes (ucp1 y ucp2) de un nuevo agonista adrenergico beta3 en un modelo de obesidad inducido con una dieta de cafeteria."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Berraondo Lopez <\/strong><\/h2>\n<p>La obesidad es una enfermedad compleja causada por un desequilibrio cr\u00f3nico entre la ingesta energ\u00e9tica y el gasto energ\u00e9tico. Los agonistas adren\u00e9rgicos beta3 muestran importantes efectos lipol\u00edticos, termog\u00e9nicos e hipoglucemiantes siendo potencialmente aplicables en el tratamiento de la obesidad y diabetes.  en el presente trabajo se ha estudiado los efectos en la utilizaci\u00f3n energ\u00e9tica y en la expresi\u00f3n del gen de la obesidad y prote\u00ednas desacoplantes (ucp1 y ucp2) de un nuevo agonista adren\u00e9rgico beta3, trecadrine, en un modelo de obesidad inducido por una dieta de cafeteria en ratas wistar hembras. La administraci\u00f3n de trecadrine durante 35 d\u00edas (1 mg\/kg) a los animales obesos disminuy\u00f3 significativamente el peso corporal y los dep\u00f3sitos grasos. Esta disminuci\u00f3n esta relacionada con un aumento de la lip\u00f3lisis en grasa blanca y grasa parda, ya que el trecadrine exhibe una potente acci\u00f3n lipol\u00edtica in vitro y aumenta la actividad de la lipasa sensible a hormonas y el consumo de ox\u00edgeno in vitro en grasa blanca. Al mismo tiempo, la administraci\u00f3n de trecadrine (1mg\/g) durante 35 d\u00edas a ratas obesas produce un aumento de la termog\u00e9nesis, reflejado por un aumento en el consumo de ox\u00edgeno in vitro en grasa parda y temperatura rectal. estos efectos est\u00e1n mediados por un aumento en la expresi\u00f3n de ucp1 en grasa parda y ucp2 en m\u00fasculo gastrocnemio, cuyos principales moduladores parecen ser los \u00e1cidos grasos movilizados al estimularse la lip\u00f3lisis. sin embargo, la expresi\u00f3n de ucp2 en m\u00fasculo gastrocnemio disminuy\u00f3 en las ratas controles tratadas con trecadrine (1mg\/kg) durante 35 d\u00edas, lo cual sugiere una respuesta diferente del trecadrine en animales controles y obesos. Asimismo, la administraci\u00f3n de trecadrine (1 mg\/kg) a los animales obesos disminuy\u00f3 los niveles plasm\u00e1ticos de leptina y los niveles de expresi\u00f3n del gen de la obesidad. En relaci\u00f3n al metabolismo gluc\u00eddico, la insulinemia dism<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos en la utilizacion energetica y en la expresion del gen de la obesidad y proteinas desacoplantes (ucp1 y ucp2) de un nuevo agonista adrenergico beta3 en un modelo de obesidad inducido con una dieta de cafeteria.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos en la utilizacion energetica y en la expresion del gen de la obesidad y proteinas desacoplantes (ucp1 y ucp2) de un nuevo agonista adrenergico beta3 en un modelo de obesidad inducido con una dieta de cafeteria. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Berraondo Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Pilar Fernandez Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Zamora navarro <\/li>\n<li>jordi Salas i salvado (vocal)<\/li>\n<li>Ana Barber c\u00e1rcamo (vocal)<\/li>\n<li>amparo Calleja canelas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Berraondo Lopez La obesidad es una enfermedad compleja causada por un desequilibrio cr\u00f3nico entre la ingesta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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