{"id":42257,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/brucelosis-humana-significado-de-las-inmunoglobulinas-anti-lipopolisacarido-anti-polisacarido-b-y-anti-proteinas-en-la-evaluacion-clinica-de-la-enfermedad\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"brucelosis-humana-significado-de-las-inmunoglobulinas-anti-lipopolisacarido-anti-polisacarido-b-y-anti-proteinas-en-la-evaluacion-clinica-de-la-enfermedad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/brucelosis-humana-significado-de-las-inmunoglobulinas-anti-lipopolisacarido-anti-polisacarido-b-y-anti-proteinas-en-la-evaluacion-clinica-de-la-enfermedad\/","title":{"rendered":"Brucelosis humana: significado de las inmunoglobulinas anti-lipopolisacarido, anti-polisacarido b y anti-proteinas en la evaluacion clinica de la enfermedad."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa Marrodan Ciordia <\/strong><\/h2>\n<p>Los objetivos de este trabajo eran: (i), caracterizar qu\u00edmicamente el polisac\u00e1rido b; (ii), analizar la participaci\u00f3n de los anticuerpos igm, igg e iga en las distintas pruebas serol\u00f3gicas utilizadas en el diagn\u00f3stico de la brucelosis humana, as\u00ed como analizar la evoluci\u00f3n de los anticuerpos frente a prote\u00ednas de brucella; y (iii), valorar dos nuevas pruebas serol\u00f3gicas para el diagn\u00f3stico de la brucelosis humana, una prueba r\u00e1pida, para la detecci\u00f3n de anticuerpos igm que reaccionan con el lps (dipstick igm) y otra prueba, basada en un m\u00e9todo de inmunocaptura-aglutinaci\u00f3n, que permite cuantificar los anticuerpos totales frente a brucella (brucellacapt(r)).  el polisac\u00e1rido b se obtuvo de las colonias peque\u00f1as de un cultivo de b. Melitensis 115 en agar patata glicerinada (72 h a 37.C). El estudio de la composici\u00f3n qu\u00edmica y estructural ha demostrado que el componente mayoritario del polisac\u00e1rido b es la n-formilperosamina y que no contiene quinovosamina ni kdo. Adem\u00e1s, los anticuerpos igm e igg reaccionan con el polisac\u00e1rido b en las pruebas de precipitaci\u00f3n en gel, siendo las subelases igg2 e igg4 las que muestran mayor capacidad de reacci\u00f3n.  el estudio realizado con las fracciones igm, igg e iga1, purificadas de sueros de pacientes con brucelosis, demuestra que los anticuerpos igm, igg e iga intervienen en las pruebas de rb y sat y que en ocasiones, la capacidad aglutinante de la igg puede verse bloqueada por la presencia de iga; adem\u00e1s, los anticuerpos iga son responsables de los fen\u00f3menos de bloqueo y de zona. Por otra parte, s\u00f3lo los anticuerpos igg e iga intervienen en la prueba de coombs. respecto a la fc, s\u00f3lo los anticuerpos igm e igg participan en la reacci\u00f3n aunque a veces, la igm puede no fijar el complemento. El estudio de la evoluci\u00f3n de los anticuerpos frente a prote\u00ednas citos\u00f3licas de brucella ha revelado que, en los pacientes tratados y sin recidiva, aunque disminuye el t\u00edtulo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Brucelosis humana: significado de las inmunoglobulinas anti-lipopolisacarido, anti-polisacarido b y anti-proteinas en la evaluacion clinica de la enfermedad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Brucelosis humana: significado de las inmunoglobulinas anti-lipopolisacarido, anti-polisacarido b y anti-proteinas en la evaluacion clinica de la enfermedad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa Marrodan Ciordia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Luis D\u00edaz Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Ordu\u00f1a domingo <\/li>\n<li>ignacio Alberola gomez-escolar (vocal)<\/li>\n<li>encarnaci\u00f3n Clavijo frutos (vocal)<\/li>\n<li>ignacio Moriyon uria (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa Marrodan Ciordia Los objetivos de este trabajo eran: (i), caracterizar qu\u00edmicamente el polisac\u00e1rido b; (ii), analizar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,155,35,9,278,597,17749],"tags":[27830,24861,18055,10696,10691,106395],"class_list":["post-42257","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-microbiologia","category-microbiologia-clinica","category-navarra","tag-antonio-orduna-domingo","tag-encarnacion-clavijo-frutos","tag-ignacio-alberola-gomez-escolar","tag-ignacio-moriyon-uria","tag-ramon-luis-diaz-garcia","tag-teresa-marrodan-ciordia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42257"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42257\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}