{"id":42303,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/trasplante-cardiaco-ortotopico-analisis-multifactorial-funcional-y-morfologico-de-la-coronariopatia-acelerada-del-injerto\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"trasplante-cardiaco-ortotopico-analisis-multifactorial-funcional-y-morfologico-de-la-coronariopatia-acelerada-del-injerto","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/trasplante-cardiaco-ortotopico-analisis-multifactorial-funcional-y-morfologico-de-la-coronariopatia-acelerada-del-injerto\/","title":{"rendered":"Trasplante cardiaco ortotopico: analisis multifactorial funcional y morfologico de la coronariopatia acelerada del injerto."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Di Stefano Salvatore <\/strong><\/h2>\n<p>Introduccion: la coronariopat\u00eda acelerada del injerto (cai) es la complicaci\u00f3n que m\u00e1s condiciona la supervivencia del trasplante cardiaco a largo plazo. La etiopatogenia de este proceso es en gran medida desconocida. La apoptosis es un tipo de muerte celular programada, relacionada con las lesiones mioc\u00edticas de la cardiopat\u00eda isqu\u00e9mica y el rechazo agudo del trasplante experimental, en cuya regulaci\u00f3n intervienen mecanismos inmunol\u00f3gicos, gen\u00e9ticos, y bioqu\u00edmicos.  objetivos.. El objetivo de este trabajo es analizar retrospectivamente los factores asociados a la cai en nuestra serie de enfermos trasplantados en la cl\u00ednica universitaria de navarra (cun), y la influencia del tratamiento inmunosupresor. adem\u00e1s se analizan las lesiones celulares por apoptosis, su relaci\u00f3n con la cai y con los estudios arteriograficos y se determinan con inmunohistoqu\u00edmica el c-myc, p53 y bc12.  material y metodos: desde agosto 1984 hasta diciembre 1996, se han realizado en la cun 147 trasplantes cardiacos. de estos se han seleccioando 102 pacientes (edad 48.7+-15.1; 0.1-70) con un seguimiento m\u00ednimo de un a\u00f1o que inclu\u00eda la realizaci\u00f3n de coronariograf\u00eda anual, llegando a realizar un diagn\u00f3stico de cai en 30 pacientes. Se han analizado las siguientes variables: edad del receptor y del donante, cardiopat\u00eda previa, compatibilidad hla, tiempo de isquemia, tensi\u00f3n arterial, glucemia, triglic\u00e9ridos, colesterol. \u00e1cido \u00farico, tratamiento inmunosupresor, episodios de rechado agudo e infecciones por citomegalovirus (cmv). se realiz\u00f3 an\u00e1lisis estad\u00edstico univariante y un modelo de regresi\u00f3n de cox multivariado. Usando la t\u00e9cnica del tunel (teminal deoxytransferase mediated bio-dutp nick-end labelling) se estudi\u00f3 la apoptosis mioc\u00e1rdica en los pacientes con cai, compar\u00e1ndolos con un grupo control de 30 trasplantados sin cai. Se realiz\u00f3 la siguiente clasificaci\u00f3n: grado 0: no apoptosis, 1: ligera-focal, 2: modera<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Trasplante cardiaco ortotopico: analisis multifactorial funcional y morfologico de la coronariopatia acelerada del injerto.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Trasplante cardiaco ortotopico: analisis multifactorial funcional y morfologico de la coronariopatia acelerada del injerto. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Di Stefano Salvatore <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Javier Pardo Mind\u00e1n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Herreros gonzalez <\/li>\n<li> Matias guiu fco. Javier (vocal)<\/li>\n<li>isabel Coma canella (vocal)<\/li>\n<li>Miguel Idoate (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Di Stefano Salvatore Introduccion: la coronariopat\u00eda acelerada del injerto (cai) es la complicaci\u00f3n que m\u00e1s condiciona la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,2189,10,17749,156,1601],"tags":[106470,2940,81288,17967,106471,106472],"class_list":["post-42303","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-cardiaca","category-cirugia-de-trasplantes","category-navarra","category-patologia","category-patologia-cardiovascular","tag-di-stefano-salvatore","tag-francisco-javier-pardo-mindan","tag-isabel-coma-canella","tag-jesus-herreros-gonzalez","tag-matias-guiu-fco-javier","tag-miguel-idoate"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42303"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42303\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}