{"id":42344,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-farmacologico-de-nuevos-antidepresivos-con-accion-dual-sobre-el-receptor-serotonergico-5-ht1a-y-sobre-el-transportador-de-5-ht\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-farmacologico-de-nuevos-antidepresivos-con-accion-dual-sobre-el-receptor-serotonergico-5-ht1a-y-sobre-el-transportador-de-5-ht","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-farmacologico-de-nuevos-antidepresivos-con-accion-dual-sobre-el-receptor-serotonergico-5-ht1a-y-sobre-el-transportador-de-5-ht\/","title":{"rendered":"Estudio farmacologico de nuevos antidepresivos con accion dual sobre el receptor serotonergico 5-ht1a y sobre el transportador de 5-ht."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Mar\u00eda Tordera Baviera <\/strong><\/h2>\n<p>Estudios recientes han mostrado que la terapia combinada de un antagonista de los receptores 5-htsub1a presin\u00e1pticos con un isrs reduce el tiempo de latencia para la aparici\u00f3n de la respuesta antidepresiva en los pacientes deprimidos. El vn 2222 es el resultado de un screening de una serie de derivados de 3-(4-arilpiperazin-1-il)-1-(benzo(b)tiofen-3-il)propano. los estudios de fijaci\u00f3n de radioligandos han mostrado que este compuesto tiene una afinidad elevada hacia el transportador de 5-ht ( ki=20 nm) y hacia el receptor 5-htsub1a(ki=20 nm). El compuesto vn 2222 inhibi\u00f3 selectivamente la recaptaci\u00f3n de 3h-5-ht in vitro en los sinaptosomas corticales de rata (ki=14 nm), y tambi\u00e9n en los estudios de microdi\u00e1lisis, donde este compuesto administrado localmente, aument\u00f3 significativamente los niveles basales de la 5-ht extracelular en el hipocampo ventral de rata, hasta un 400%. La administraci\u00f3n sist\u00e9mica de dosis bajas del vn 2222 (0,01-0,1 mg\/kg) inhibi\u00f3 la recaptaci\u00f3n de 3h-5-ht ex vivo y aument\u00f3 los niveles de 5-ht extracelular en los estudios de microdi\u00e1lisis; sin embargo dosis m\u00e1s elevadas del compuesto resultaron inefectivas. En los estudios de temperatura rectal en rat\u00f3n, el vn 2222 (0,01-0,1 mg\/kg, ip) antagoniz\u00f3 parcialmente la hipotermia producida por el 8-oh-dpat sugiriendo propiedades antagonistas de los receptores 5-htsub1a presin\u00e1pticos, en este rango de dosis. igualmente, en el test de porsolt, modelo animal de depresi\u00f3n, el compuesto vn 2222 mostr\u00f3 una acci\u00f3n bif\u00e1sica al reducir significativamente el tiempo de inmovilidad en el rango de dosis 0,001-0,1 mg\/kg pero no a dosis m\u00e1s elevadas. Adem\u00e1s la actividad antidepresiva de este compuesto se confirm\u00f3 en el test de la indefensi\u00f3n aprendida donde result\u00f3 claramente efectivo. Puesto que el compuesto revel\u00f3 cierta afinidad hacia los receptores adren\u00e9rgicos alfa1 se sugiere que el efecto bif\u00e1sico observado en este compuesto es el resultado<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacologico de nuevos antidepresivos con accion dual sobre el receptor serotonergico 5-ht1a y sobre el transportador de 5-ht.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacologico de nuevos antidepresivos con accion dual sobre el receptor serotonergico 5-ht1a y sobre el transportador de 5-ht. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Mar\u00eda Tordera Baviera <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Del Rio Zambrana<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  isabel Cadavid torres <\/li>\n<li>Antonio Monge vega (vocal)<\/li>\n<li>edurne Cenarruzabeitia sagarminaga (vocal)<\/li>\n<li>joan Roca acin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Mar\u00eda Tordera Baviera Estudios recientes han mostrado que la terapia combinada de un antagonista de los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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