{"id":42346,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":""},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-del-patron-del-eje-gh-igf-i-y-sus-proteinas-transportadoras-en-diferentes-estadios-de-la-cirrosis-hepatica-experimental-compensada-y-ascitica-efecto-del-tratamiento-con-el-factor-de-crecimie","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-patron-del-eje-gh-igf-i-y-sus-proteinas-transportadoras-en-diferentes-estadios-de-la-cirrosis-hepatica-experimental-compensada-y-ascitica-efecto-del-tratamiento-con-el-factor-de-crecimie\/","title":{"rendered":"Estudio del patron del eje gh\/igf- i y sus proteinas transportadoras en diferentes estadios de la cirrosis hepatica experimental compensada y ascitica. efecto del tratamiento con el factor de crecimiento semejante a la insulina tipo i (igf-i)."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Aliaga Montilla M. Aurelia <\/strong><\/h2>\n<p>Introduccion.- En estadios avanzados de cirrosis, insuficiencia hepatocelular e hipertensi\u00f3n portal se complican por una desnutrici\u00f3n progresiva que empeora el pron\u00f3stico. Dosis bajas de igf-i son eficaces, mejorando: estado nutricional, absorci\u00f3n intestinal, osteopenia e hipogonadismo. El eje gh\/igf-i se altera, descendiendo las concentraciones plasm\u00e1ticas de igf-i e incrementando las de gh.  objetivos.- 1. Establecer patr\u00f3n del eje gh\/igf-i en cirrosis compensada, con pruebas funcionales de secreci\u00f3n de gh (tono somatostatin\u00e9rgico); 2. Dilucidar patr\u00f3n de igfbps en cirrosis compensada; 3. Establecer patr\u00f3n del eje gh\/igf-i y de sus igfbps en cirrosis descompensada.  material y metodos.- Inducci\u00f3n de cirrosis por inhalaci\u00f3n de ccl4 y fenobarbital en agua de bebida en ratas wistar macho: a) protocolo i (estadio compensado): per\u00edodo de 11 semanas con ccl4 y tratamiento de 2 semanas con igf-i a bajas dosis (2  g\/100 g pc\/d\u00eda); experimento adicional \u00abin vivo\u00bb con pruebas funcionales de secreci\u00f3n de gh, valorando tono somatostatin\u00e9rgico por inhibici\u00f3n de secreci\u00f3n de somatostatina (ss) con piridostigmina (pd, anticolinester\u00e1sico) (n=22); b) protocolo ii (estadio descompensado): per\u00edodo de 30 semanas con ccl4 y tratamiento de 3 semanas con igf-i (n=10); y c) protocolo iii (estadio compensado): experimento agudo \u00abin vivo\u00bb con bolus de igf-i (2  g\/100 g pc) (n=5).  resultados.- Las concentraciones de igf-i en suero se elevaron ligeramente y las de gh descendieron en ratas con cirrosis incipiente (p=ns co vs cl y cl+igf); esta relaci\u00f3n co vs cl y cl+igf); se recuperaron con tratamiento con igf-i cl+igf) respectivamente; las concentraciones de igfbp-3 se cl+igf); igualmente mejoraron con tratamiento con igf-i compensada (p=ns co vs cl y cl+igf). Las ratas con cirrosis compensada no respondieron al est\u00edmulo con pd (inhibidor de la ss), permaneciendo constantes las concentraciones de gh en suero; las ratas cirr\u00f3ticas t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del patron del eje gh\/igf- i y sus proteinas transportadoras en diferentes estadios de la cirrosis hepatica experimental compensada y ascitica. efecto del tratamiento con el factor de crecimiento semejante a la insulina tipo i (igf-i).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del patron del eje gh\/igf- i y sus proteinas transportadoras en diferentes estadios de la cirrosis hepatica experimental compensada y ascitica. efecto del tratamiento con el factor de crecimiento semejante a la insulina tipo i (igf-i). <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Aliaga Montilla M. Aurelia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Castilla Cortazar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>Juan  ignacio Arenas mirave (vocal)<\/li>\n<li>Jos\u00e9 Narvaez bueno (vocal)<\/li>\n<li>bruno Sangro g\u00f3mez-acebo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Aliaga Montilla M. Aurelia Introduccion.- En estadios avanzados de cirrosis, insuficiencia hepatocelular e hipertensi\u00f3n portal se complican [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[467,9,2931,466,17749],"tags":[106538,18316,13077,15059,106539,28538],"class_list":["post-42346","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-nutricion","category-ciencias-medicas","category-enfermedades-de-la-nutricion","category-metabolismo-energetico","category-navarra","tag-aliaga-montilla-m-aurelia","tag-bruno-sangro-gomez-acebo","tag-inmaculada-castilla-cortazar","tag-jesus-m-prieto-valtuena","tag-jose-narvaez-bueno","tag-juan-ignacio-arenas-mirave"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42346"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42346\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}