{"id":42348,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":""},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"mecanismos-fisiopatologicos-y-efectos-terapeuticos-del-factor-de-crecimiento-semejante-a-la-insulina-tipo-i-igf-i-en-la-atrofia-testicular-asociada-a-cirrosis-hepatica-avanzada-y-en-la-inducida-por","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mecanismos-fisiopatologicos-y-efectos-terapeuticos-del-factor-de-crecimiento-semejante-a-la-insulina-tipo-i-igf-i-en-la-atrofia-testicular-asociada-a-cirrosis-hepatica-avanzada-y-en-la-inducida-por\/","title":{"rendered":"Mecanismos fisiopatologicos y efectos terapeuticos del factor de crecimiento semejante a la insulina tipo i (igf-i) en la atrofia testicular asociada a cirrosis hepatica avanzada y en la inducida por hipoxia cronica: estudio comparativo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Fernando Diez Caballero Alonso <\/strong><\/h2>\n<p>Introducci\u00f3n: aunque el hipogonadismo est\u00e1 frecuentemente asociado a la cirrosis hep\u00e1tica avanzada, los mecanismos fisiopatol\u00f3gicos no son bien conocidos. el factor de crecimiento semejante a la insulina tipo i (igf-i) presenta concentraciones bajas en la enfermedad avanzada hep\u00e1tica. Esta hormona estimula la s\u00edntesis de testosterona y la espermatog\u00e9nesis. En este trabajo se ha querido estudiar la posible implicaci\u00f3n de la deficiencia de igf-i en el hipogonadismo en la cirrosis hep\u00e1tica avanzada o de otras etiolog\u00edas.  material y m\u00e9todos: evaluar el efecto de igf-i sobre el hipogonadismo asociado a cirrosis hep\u00e1tica y al producido por hipoxia cr\u00f3nica. Se realizaron dos ensayos: ensayo i: tres grupos experimentales de ratas wistar macho distribuidos en grupo control sanos (co1), cirr\u00f3ticas (ci) y cirr\u00f3ticas tratadas con 2 g\/100g p.C.\/D\u00eda de igf-i subcut\u00e1nea durante 21 d\u00edas (ci+igf). la cirrosis avanzada se indujo mediante inhalaci\u00f3n de cci4 y a\u00f1adiendo fenobarbital en el agua de bebida durante 30 semanas. Ensayo ii: tres grupos experimentales de ratas wistar macho distribuidos en grupo control sanos (cosub11), atr\u00f3ficas (at) y atr\u00f3ficas tratadas con 2 g\/100g p.C.\/D\u00eda de igf-i subcut\u00e1nea durante 28 d\u00edas (at+igf). La atrofia testicular se indujo por inyecci\u00f3n intravaginal con epinefrina (1,5mg\/kg) durante 12 semanas. En ambos ensayos se realizaron funci\u00f3n hep\u00e1tica y anal\u00edtica general, el eje hipofiso-gonadal y las concentraciones de igf-i as\u00ed como estudios morfom\u00e9tricos, histopatol\u00f3gicos e inmunohistoqu\u00edmicos (malondialdehido mda, proliferaci\u00f3n celular pcna, expresi\u00f3n de transferrina, \u00f3xido n\u00edtrico sintasa inducible inos, y la enzima antioxidante glutation peroxidasa fosfol\u00edpido hiper\u00f3xido) sobre test\u00edculo. resultados: ensayo i: se confirm\u00f3 la cirrosis hep\u00e1tica avanzada histol\u00f3gicamente. Al comparar los animales co  con los ci se observ\u00f3 una marcada disminuci\u00f3n del tama\u00f1o y peso testicul<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos fisiopatologicos y efectos terapeuticos del factor de crecimiento semejante a la insulina tipo i (igf-i) en la atrofia testicular asociada a cirrosis hepatica avanzada y en la inducida por hipoxia cronica: estudio comparativo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos fisiopatologicos y efectos terapeuticos del factor de crecimiento semejante a la insulina tipo i (igf-i) en la atrofia testicular asociada a cirrosis hepatica avanzada y en la inducida por hipoxia cronica: estudio comparativo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Fernando Diez Caballero Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Inmaculada Castilla Cortazar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>Juan  Javier Zudaire bergera (vocal)<\/li>\n<li>Fernando Arocena lanz (vocal)<\/li>\n<li>Francisco Javier Alvarez-cienfuegos suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Fernando Diez Caballero Alonso Introducci\u00f3n: aunque el hipogonadismo est\u00e1 frecuentemente asociado a la cirrosis hep\u00e1tica avanzada, los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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