{"id":42355,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-de-las-moleculas-cd5-y-cd23-en-linfocitos-b-de-sangre-periferica-y-liquido-sinovial-de-pacientes-con-artritis-reumatoide\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"analisis-de-la-expresion-de-las-moleculas-cd5-y-cd23-en-linfocitos-b-de-sangre-periferica-y-liquido-sinovial-de-pacientes-con-artritis-reumatoide","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-de-la-expresion-de-las-moleculas-cd5-y-cd23-en-linfocitos-b-de-sangre-periferica-y-liquido-sinovial-de-pacientes-con-artritis-reumatoide\/","title":{"rendered":"Analisis de la expresion de las moleculas cd5 y cd23 en linfocitos b de sangre periferica y liquido sinovial de pacientes con artritis reumatoide."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Loza Cortina <\/strong><\/h2>\n<p>Metodos: hemos estudiado en sangre perif\u00e9rica (sp) y l\u00edquido sinovial (ls) de 31 pacientes con artritis reumatoide (ar) la expresi\u00f3n de las mol\u00e9culas cd5 y cd23 en linfocitos b (lb), los niveles de cd23 soluble (scd23), interleuquina-4 (il-4), interleuquina-1beta y factor de necrosis tumoral-alfa (tnf-alfa), y su correlaci\u00f3n con el \u00edndice de actividad de la enfermedad. tambi\u00e9n hemos analizado la presencia de factores de riesgo gen\u00e9ticos para la ar como el ep\u00edtopo compartido (secuencia qkrra-qrraa codificada por alelos hla-drb1). los pacientes fueron diagnosticados de ar seg\u00fan los criterios revisados de 1987 del colegio americano de reumatolog\u00eda.  el an\u00e1lisis fenot\u00edpico de lb se realiz\u00f3 mediante citometr\u00eda de flujo. Los niveles de citoquinas se midieron mediante t\u00e9cnica elisa. La expresi\u00f3n del ep\u00edtopo reumatoide se determin\u00f3 mediante t\u00e9cnica de citometr\u00eda de flujo, los casos positivos se comprobaron mediante biolog\u00eda molecular (t\u00e9cnica pcr-ssp). La actividad de la enfermedad se barem\u00f3 utilizando el indice de stoke modificado.  resultados: los lb cd5+ est\u00e1n expandidos en ls y muestran mayor expresi\u00f3n de cd23 que los lb cd5-. Doce pacientes presentaron niveles detectables de il-4 en plasma y 10 en ls (9 en ambas muestras); la ausencia de il-4 se relacion\u00f3 con una mayor expresi\u00f3n de cd23 en lb cd5+ y con mayores niveles de scd23. Se observ\u00f3 una correlaci\u00f3n negativa en ls entre los niveles de tnf-alfa y scd23. No hubo correlaci\u00f3n entre el \u00edndice de actividad de la enfermedad y la expresi\u00f3n de cd5 y cd23 en lb y los niveles de scd23, il-4, tnf-alfa e il-1beta. No hubo diferencias en la expresi\u00f3n de cd5 y cd23 en lb, en los niveles de las citoquinas analizadas y en el \u00edndice de actividad de la enfermedad entre los pacientes con y sin expresi\u00f3n del ep\u00edtopo reumatoide.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de la expresion de las moleculas cd5 y cd23 en linfocitos b de sangre periferica y liquido sinovial de pacientes con artritis reumatoide.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de la expresion de las moleculas cd5 y cd23 en linfocitos b de sangre periferica y liquido sinovial de pacientes con artritis reumatoide. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Loza Cortina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfonso Sanchez Ibarrola<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Perez miranda <\/li>\n<li>pedro Errasti goenaga (vocal)<\/li>\n<li>Fernando Vidal vanaclocha (vocal)<\/li>\n<li>oscar Beloqui ruiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Loza Cortina Metodos: hemos estudiado en sangre perif\u00e9rica (sp) y l\u00edquido sinovial (ls) de 31 pacientes 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