{"id":42356,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-los-oncogenes-supresores-tumorales-p53-y-p16-en-el-carcinoma-transicional-de-vejiga\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-los-oncogenes-supresores-tumorales-p53-y-p16-en-el-carcinoma-transicional-de-vejiga","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-los-oncogenes-supresores-tumorales-p53-y-p16-en-el-carcinoma-transicional-de-vejiga\/","title":{"rendered":"Estudio de los oncogenes supresores tumorales p53 y p16 en el carcinoma transicional de vejiga."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martin Marquina Aspiunza Alberto <\/strong><\/h2>\n<p>Se estudian los oncogenes supresores tumorales p53, 87 muestras (exones 4-9) y p16, 77 muestras (exones 1-2), en el carcinoma de c\u00e9lulas transicionales de vejiga (tcc).  se realiza extracci\u00f3n del adn mediante el m\u00e9todo del fenol, pcr de amplificaci\u00f3n y pcr de secuenciaci\u00f3n con terminadores marcados y electroforesis en gel de acrilamida. Los resultados se comparan con el genbank. Se estudia la oncoprote\u00edna p53 mediante citometr\u00eda de flujo.  el 38% de las muestras presentan mutaci\u00f3n del p53: puntual 78%, deleciones 12% e inserciones 9%. La transversi\u00f3n ocurre en 24 casos, incluyendo 4 deleciones y 2 inserciones. La transici\u00f3n en 9 casos, incluyendo una inserci\u00f3n. El ex\u00f3n y cod\u00f3n m\u00e1s mutado es el 7 y el 195, respectivamente.  se detectan 2 mutaciones del p16 (ex\u00f3n 2), una transici\u00f3n (cod\u00f3n 107) y otra transversi\u00f3n (cod\u00f3n 91). se comparan estos resultados con factores pron\u00f3sticos conocidos del tcc.  conclusiones:  &#8211; la mutaci\u00f3n es un mecanismo infrecuente de inactivaci\u00f3n del p16 y frecuente del p53.  &#8211; la sobreexpresi\u00f3n de la oncoprote\u00edna p53 se correlaciona con el estadio patol\u00f3gico, el grado tumoral y con la mutaci\u00f3n de dicho gen.  &#8211; la mutaci\u00f3n del p53 se correlaciona con el estadio patol\u00f3gico, el tama\u00f1o tumoral, es un factor influyente independiente en el grado de diferenciaci\u00f3n celular y en la supervivencia por su frecuente asociaci\u00f3n a estadios patol\u00f3gicos avanzados.  &#8211; la presencia de mutaci\u00f3n del p53 es un factor de riesgo de recidiva en los tumores vesicales superficiales, teniendo a la multiplicidad tumoral como factor intermedio.  &#8211; el p53 se encuentra m\u00e1s mutado en los pacientes con h\u00e1bito tab\u00e1quico y si \u00e9ste es mayor de 20 cigarrillos al d\u00eda, aunque estas diferencias no llegan a ser significativas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de los oncogenes supresores tumorales p53 y p16 en el carcinoma transicional de vejiga.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de los oncogenes supresores tumorales p53 y p16 en el carcinoma transicional de vejiga. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martin Marquina Aspiunza Alberto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>David Rosell Costa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfonso Sanchez ibarrola <\/li>\n<li>Francisco Romero fernandez (vocal)<\/li>\n<li>Fernando Arocena lanz (vocal)<\/li>\n<li>Luis Sierrasesumaga ariznabarreta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martin Marquina Aspiunza Alberto Se estudian los oncogenes supresores tumorales p53, 87 muestras (exones 4-9) y p16, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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