{"id":4256,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/caracterizacion-funcional-y-fenotipica-de-los-linfocitos-t-en-sindromes-linfoproliferativos-de-celulas-b-slcb\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"caracterizacion-funcional-y-fenotipica-de-los-linfocitos-t-en-sindromes-linfoproliferativos-de-celulas-b-slcb","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/caracterizacion-funcional-y-fenotipica-de-los-linfocitos-t-en-sindromes-linfoproliferativos-de-celulas-b-slcb\/","title":{"rendered":"Caracterizacion funcional y fenotipica de los linfocitos t en sindromes linfoproliferativos de celulas b (slcb)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Lape\u00f1a Gomez <\/strong><\/h2>\n<p>Los linfocitos t de enfermos con slcb presentan alteraciones que afectan tanto a su distribucion fenotipica como a su funcionalidad. Basandonos en estos datos previos, en nuestro estudio hemos profundizado en las caracteristicas funcionales y fenotipicas de una poblacion de 33 pacientes con slcb: 5 con leucemia de celulas peludas (lcp), 10 con leucemia linfatica cronica b (llcb), 14 con mieloma multiple (mm) y 4 con macrobiobulinemia de waldenstrom (mw). Nuestros datos muestran que los linfocitos t de los pacientes con llcb, mm, mw se asocian a una alteracion funcional en la respuesta proliferativa al estimulo con mitogenos policlonales, asi como a una redistribucion de las subpoblaciones de linfocitos cd3. Tambien se observo un aumento del porcentaje de celulas nr y de linfocitos t citotoxicos activados en la sangre periferica de los pacientes con mm. Por otra parte, se aprecio que los linfocitos t de dichos pacientes con mm presentan una produccion de interleucina-6 aumentada, que podria estar relacionada con el desarrollo de la enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion funcional y fenotipica de los linfocitos t en sindromes linfoproliferativos de celulas b (slcb)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion funcional y fenotipica de los linfocitos t en sindromes linfoproliferativos de celulas b (slcb) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Lape\u00f1a Gomez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Melchor Alvarez De Mon Soto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Horacio Rico Lenza <\/li>\n<li>Julia Jorda Tormo (vocal)<\/li>\n<li>Rafael Laguna (vocal)<\/li>\n<li>Antonio Giron Jose (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Lape\u00f1a Gomez Los linfocitos t de enfermos con slcb presentan alteraciones que afectan tanto a su 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