{"id":42620,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-bioquimicos-de-pancreatitis-aguda-alcoholica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"marcadores-bioquimicos-de-pancreatitis-aguda-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-bioquimicos-de-pancreatitis-aguda-alcoholica\/","title":{"rendered":"Marcadores bioquimicos de pancreatitis aguda alcoholica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Ramon Aparicio Tormo <\/strong><\/h2>\n<p>La distinci\u00f3n temprana entre pancreatitis aguda alcoh\u00f3lica (paa) y biliar (pab) es transcendente, ya que condiciona diferencias importantes en el tratamiento. se ha propuesto que la transferrina deficiente en carbohidratos (cdt) y la actividad de la tripsina (at) son \u00fatiles en el diagn\u00f3stico de paa. Objetivos: determinar los niveles de cdt y de at en pacientes con pa y valorar su utilidad en el diagn\u00f3stico de paa.  material y m\u00e9todos: se estudiaron de forma retrospectiva 70 pacientes con diagn\u00f3stico de pa (36 pab, 16 paa, 11 pa idiop\u00e1tica (pai) y 7 de otras etiolog\u00edas (pao), 32 alcoh\u00f3licos asintom\u00e1ticos (aa) y 16 controles sanos (cs). Posteriormente se validaron los resultados de forma prospectiva en 70 pacientes con pa: 42 pab, 14 paa y 14 pai. Resultados: los niveles de cdt fueron sifnificativamente m\u00e1s altos (p&lt;0.00001) en los pacientes con paa que en el resto de etiolog\u00edas y en los cs, aunque sin diferencias con respecto a los aa, mediana (p25-p75) paa: 30.8 (23.6-41.7); aa: 31 (22.1-39.1), pab. 16.7 (13.05-21.1), pai: 17.5 (15.9-21.6); pao: 19.3 (15-1-27.7); cs: 16.1 (12.1-18.8). Con un punto de corte de 22.5 u\/l en los niv\u00e9les de cdt se obtiene una sensibilidad del 87.5%, especificidad 85.2%, vpp lo.L% y vpn del 95.8% para diferenciar entre paa y no alcoh\u00f3lica. Los niveles de la at fueron significativamente m\u00e1s altos (p=0.0001) en los pacientes con paa con respecto a los dem\u00e1s grupos; mediana (p25-p75): paa: 165 (76-405); pab: mk.K (52.5-101.3); pa i: 48 (41-93); aa: 63 (37-88.5); cs: 39(33-43). Con un punto de corte de 152 u\/l, e obtiene una sensibilidad del 60%, especificidad 100%, vpp del 100% y vpn 86%. Se dise\u00f1\u00f3 una curva roc para comaprar la utilidad de ambos marcadores no encontrando diferencias significativas entre ambos: \u00e1rea bajo la curva (ic95%): cdt: 0.914+0.05 (0.822-0.967): at: 0.803+-0.074 (0.669-0.9): p=0.137. Utilizando un m\u00f3delo de regresi\u00f3n log\u00edstica m\u00faltiple en el que se inclu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores bioquimicos de pancreatitis aguda alcoholica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores bioquimicos de pancreatitis aguda alcoholica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Ramon Aparicio Tormo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Perez Mateo Regadera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino sanchez <\/li>\n<li>Miguel Bixquert jimenez (vocal)<\/li>\n<li>salvador Navarro colas (vocal)<\/li>\n<li>Luis Aparisi quereda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Ramon Aparicio Tormo La distinci\u00f3n temprana entre pancreatitis aguda alcoh\u00f3lica (paa) y biliar (pab) es transcendente, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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