{"id":42663,"date":"2018-03-09T09:44:38","date_gmt":"2018-03-09T09:44:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-inmunohistoquimica-de-genes-supresores-p-53-y-retinoblastoma-oncogen-bcl2-y-marcadores-de-proliferacion-pcna-y-ki67-en-carcinoma-de-laringe\/"},"modified":"2018-03-09T09:44:38","modified_gmt":"2018-03-09T09:44:38","slug":"expresion-inmunohistoquimica-de-genes-supresores-p-53-y-retinoblastoma-oncogen-bcl2-y-marcadores-de-proliferacion-pcna-y-ki67-en-carcinoma-de-laringe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-inmunohistoquimica-de-genes-supresores-p-53-y-retinoblastoma-oncogen-bcl2-y-marcadores-de-proliferacion-pcna-y-ki67-en-carcinoma-de-laringe\/","title":{"rendered":"Expresion inmunohistoquimica de genes supresores p 53 y retinoblastoma, oncogen bcl2 y marcadores de proliferacion pcna y ki67 en carcinoma de laringe."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Urpegui Garcia Angel Miguel <\/strong><\/h2>\n<p>Actualmente el cancer est\u00e1 apareciendo encuadrado como la enfermedad gen\u00e9tica m\u00e1s com\u00fan en el hombre, utilizando el t\u00e9rmino gen\u00e9tica en un sentido restrictivo y referido a las variaciones que se producen en los distintos genes, y que aparecen involucrados en la transformaci\u00f3n evolutiva de una c\u00e9lula normal a una c\u00e9lula neopl\u00e1sica.  el carcinoma de laringe representa el 1% de los tumores del organismo y el 25% de la patolog\u00eda oncol\u00f3gica de la cabeza y cuello. En la actualidad carecemos de par\u00e1metros v\u00e1lidos que nos permitan establecer un pron\u00f3stico con seguridad. Por este motivo hemos seleccionado unos marcadores que, por medio de la inmunohistoqu\u00edmica nos permitan predecir con mayor acierto el comportamiento neopl\u00e1sico.  en este trabajo hemos determinado la expresi\u00f3n de dos genes supresores tumorales, el p53 y el rb; un oncog\u00e9n, el bcl-2; y dos marcadores de proliferaci\u00f3n celular, el pcna y el ki-67, todo ello en 72 carcinomas de laringe.  posteriormente llevamos a cabo una correlaci\u00f3n anatomocl\u00ednica con los par\u00e1metros cl\u00e1sicos (clasificaci\u00f3n tnm, grado tumoral, edad, tabaco, etc&#8230;), Descubriendo diferencias estad\u00edsticamente significativas en la media de expresi\u00f3n para algunos grupos. de este modo optuvimos una correlaci\u00f3n positiva de los marcadores rb, bc12, pcna y ki67 con respecto al grado de diferenciaci\u00f3n celular, y de los marcadores rb, bc12 y ki67 con respecto al estadio n tumoral.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion inmunohistoquimica de genes supresores p 53 y retinoblastoma, oncogen bcl2 y marcadores de proliferacion pcna y ki67 en carcinoma de laringe.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion inmunohistoquimica de genes supresores p 53 y retinoblastoma, oncogen bcl2 y marcadores de proliferacion pcna y ki67 en carcinoma de laringe. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Urpegui Garcia Angel Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Jose Morandeira Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9p Traserra parareda <\/li>\n<li>Jos\u00e9 Morales asin (vocal)<\/li>\n<li>Santiago Ramon y cajal junquera (vocal)<\/li>\n<li>Antonio Morell\u00f3 castro (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Urpegui Garcia Angel Miguel Actualmente el cancer est\u00e1 apareciendo encuadrado como la enfermedad gen\u00e9tica m\u00e1s com\u00fan en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,52,156,13610],"tags":[20375,107049,73,28635,28599,107048],"class_list":["post-42663","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-histopatologia","category-patologia","category-zaragoza","tag-antonio-morello-castro","tag-jose-morales-asin","tag-josep-traserra-parareda","tag-maria-jose-morandeira-garcia","tag-santiago-ramon-y-cajal-junquera","tag-urpegui-garcia-angel-miguel"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42663"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42663\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}