{"id":42698,"date":"1999-05-02T00:00:00","date_gmt":"1999-05-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/peptidos-sinteticos-contra-el-virus-de-la-hepatitis-a-diseno-de-estructuras-inmunoadyuvantes\/"},"modified":"1999-05-02T00:00:00","modified_gmt":"1999-05-02T00:00:00","slug":"peptidos-sinteticos-contra-el-virus-de-la-hepatitis-a-diseno-de-estructuras-inmunoadyuvantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/peptidos-sinteticos-contra-el-virus-de-la-hepatitis-a-diseno-de-estructuras-inmunoadyuvantes\/","title":{"rendered":"Peptidos sinteticos contra el virus de la hepatitis a. dise\u00f1o de estructuras inmunoadyuvantes"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Monica Garcia Lopez <\/strong><\/h2>\n<p>El objetivo inicial de esta tesis doctoral era la contribucion al futuro dise\u00f1o de una vacuna de origen quimico contra el virus de la hepatitis a. En este sentido se ha llevado a cabo la sintesis en fase solida de la secuencia hav-vp3(102-121) y su palmitoil-derivado. Esta secuencia se ha conjugado a tres polimeros sinteticos ramificados mediante enlace disulfuro o amida obteniendose seis inmunogenos de distinta polaridad y orientaci\u00f3n de epitopos. Se han formulado ademas las secuencias peptidicas en liposomas mediante encapsulaci\u00f3n en su interior, incorporaci\u00f3n entre las bicapas fosfolipidicas o uni\u00f3n covalente a la superficie de la vesicula. Todas las formulaciones obtenidas se han caracterizado desde el punto de vista estructural, realizando un estdio mediante dicroismo circular, y desde el punto de vista fisicoquimico, estudiando su interacci\u00f3n con modelos de biomembrana como las monocapas y bicapas fosfolipidicas. Se ha estudiado ademas la antigenicidad de estas estructuras mediante la tecnica de resonancia en plasmon superficial. La evaluaci\u00f3n inmunologica de la secuencia permite concluir que \u00e9sta es una firme candidata aformar parte de una vacuna de origen quimico contra el virus de la hepatitis a.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Peptidos sinteticos contra el virus de la hepatitis a. dise\u00f1o de estructuras inmunoadyuvantes<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Peptidos sinteticos contra el virus de la hepatitis a. dise\u00f1o de estructuras inmunoadyuvantes <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Monica Garcia Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/02\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Asuncion Alsina Esteller<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Mi\u00f1onez trillo <\/li>\n<li>ernest Giralt lledo (vocal)<\/li>\n<li>oriol Valls planells (vocal)<\/li>\n<li>angel Messeguer peypoch (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Monica Garcia Lopez El objetivo inicial de esta tesis doctoral era la contribucion al futuro dise\u00f1o de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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