{"id":4271,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/metabolismo-del-agua-deuterada-en-higado-de-roedores-detectado-por-resonancia-nuclear\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"metabolismo-del-agua-deuterada-en-higado-de-roedores-detectado-por-resonancia-nuclear","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/metabolismo-del-agua-deuterada-en-higado-de-roedores-detectado-por-resonancia-nuclear\/","title":{"rendered":"Metabolismo del agua deuterada en higado de roedores, detectado por resonancia nuclear"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Milagros Moldes Rodriguez <\/strong><\/h2>\n<p>Se presenta un estudio del metabolismo a corto plazo del agua pesada (2h2o) en higado perfundido de roedores realizado con resonancia magnetica nuclear (rmn) y tecnicas metabolicas convencionales. Se perfundieron higados de rata o de raton con (13c) alanina en tampon krebs ringer bicarbonato conteniendo o no 50% 2h2o y se determino; (i) la cinetica de entrada de 2h2o en el higado, (ii) los efectos del 2h2o sobre el metabolismo de alanina y (iii) los intercambios de protones por deuterones del solvente.  la entrada de 2h2o en higado, detectada por 2h rmn, siguio una cinetica biexponencial con constantes de velocidad de 9,6 y 96 s-1, respectivamente. La vida media del 2h2o en el higado fue de 10,4 ms.  la sustitucion de 50% del agua del krb por 2h2o, redujo a la mitad los consumos hepaticos de oxigeno o alanina, disminuyo considerablemente la sintesis del glucogeno. Los espectros de 31p rmn tomados durante la perfusion indicaron que el 2h2o inhibe el descenso de phi causado por la alanina e induce la hidrolisis de fosfatidicolina. Los efectos del agua deuterada sobre el phi y sobre el metabolismo de fosfolipidos fueron similares a los inducidos por dids u ouabaina. Estos resultados sugieren que el 2h2o inhibe el antitransportador na+\/h+ y no afecta a los transportadores hco3-\/na+ y hco3 \/ci o a la atpasa na+\/k+.  el analisis por 13c rmn de los desplazamientos isotopos y de de los acoplamientos 13c-2h revelaron un intercambio 1h-2h diferencial, dependiendeo de la naturaleza del metabolito y de la posicion del marcaje en 13c. Los isotopomeros (3-13c) aspartato mostraron relaciones 2h\/1h similares en los carbonos c2 y c3, mientras que los isotopomeros (2-13c) aspartato tuvieron una relacion 2h\/1h mucho menor en c2 que en c3. Estos resultados indican que los intercambios 1h-2h en las relaciones dehidratacion-deshidratacion del ciclo de krebs que produce el intercambio sobre el c3 de aspartato y glutamato son mas rapidos que los in<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo del agua deuterada en higado de roedores, detectado por resonancia nuclear<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo del agua deuterada en higado de roedores, detectado por resonancia nuclear <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Milagros Moldes Rodriguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>esteller Cerd\u00e1n Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jose Luque Cabrera <\/li>\n<li>\u00e1ngeles Mart\u00edn Requero (vocal)<\/li>\n<li>Manuel Rico Samropas (vocal)<\/li>\n<li>Carles Ar\u00fas Caralt\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Milagros Moldes Rodriguez Se presenta un estudio del metabolismo a corto plazo del agua pesada (2h2o) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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