{"id":42760,"date":"1999-05-03T00:00:00","date_gmt":"1999-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-somatostatina-y-de-los-aportadores-de-grupos-tioles-en-la-prevencion-del-dano-postreperfusion-durante-la-isquemia-intestinal\/"},"modified":"1999-05-03T00:00:00","modified_gmt":"1999-05-03T00:00:00","slug":"papel-de-la-somatostatina-y-de-los-aportadores-de-grupos-tioles-en-la-prevencion-del-dano-postreperfusion-durante-la-isquemia-intestinal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-la-somatostatina-y-de-los-aportadores-de-grupos-tioles-en-la-prevencion-del-dano-postreperfusion-durante-la-isquemia-intestinal\/","title":{"rendered":"Papel de la somatostatina y de los aportadores de grupos tioles en la prevencion del da\u00f1o postreperfusion, durante la isquemia intestinal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan Ariceta Iraola <\/strong><\/h2>\n<p>Introduccion: la isquemia intestinal es una patolog\u00eda cada vez m\u00e1s frecuente en nuestros hospitales. Aunque son amplios los conocimientos sobre su patogenia, todavia nose conoce un tratamiento capaz de prevenir la progresi\u00f3n del da\u00f1o por isquemia reperfusi\u00f3n (i-r).  nosotros hemos desarrollado un modelo experimental de isquemia-reperfusi\u00f3n (i-r) y realizado ensayos terapeuticos con antioxidantes como la n-aceticiste\u00edna (nac), el alopurinol (alp) y la somatostatina (smt).  material y metodos: utilizamos ratas wistar con un peso entre 250 y 300 gr. En ayunas de 24h y acceso libre al agua. Se anestesian con ketamina, atropina y valium, cumpliendo siempre la normativa de utilizaci\u00f3n de animales de laboratorio. Se realiz\u00f3 el estudio estadistico con el test \u00abt student\u00bb.  modelo de i-r: clampaje de la arteria mesenterica superior (60 min) y reperfusion tras el desclampaje de la misma (150 min). Posteriormente los animales son sacrificados mediante exanguinacion estudiandose: tama\u00f1o de la necrosis intestinal, histolog\u00eda de la porcion isquemica y el intestino isquemico e intermedio, pulmon e higado: gsh, mda, mpo, atp, en corazon: gsh,mda,atp y en sangre periferica: gsh,mda, amilasa.  grupos: control, i.R.I. Sin tratamiento, smt (4,16 mg\/kg), nac (3 gr\/kg), alp(100 mg\/kg: 50% dosis en el periodo isquemico y 50% durante la reperfusion), smt\/nac, nac\/alp.  resultados y discusion:  1. El tama\u00f1o de la necrosis intestinal en nuestro modelo experimental pudo reducirse hasta un 60% con el uso de alp y nac. El alp fue el m\u00e1s eficaz. a administraci\u00f3n conjunta de ambos f\u00e1rmacos no mejor\u00f3 los resultados.  2. El intestino necrotico present\u00f3 una importante disminuci\u00f3n de gsh e incremento de mpo. En el intestino con isquemia intermedia s\u00f3lo se observo un incremento en el mpo, que ademas pudo prevenirse con la administracion de smt i.V., La correccion de esta alteraci\u00f3n metabolica presupone la viabilidad del intestino con isquemia interm<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la somatostatina y de los aportadores de grupos tioles en la prevencion del da\u00f1o postreperfusion, durante la isquemia intestinal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la somatostatina y de los aportadores de grupos tioles en la prevencion del da\u00f1o postreperfusion, durante la isquemia intestinal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan Ariceta Iraola <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lera Tricas Jos\u00e9 M.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Carlos Garc\u00eda-valdecasas Salgado <\/li>\n<li>Daniel Casanova Rituerto (vocal)<\/li>\n<li>Javier Diez Martinez (vocal)<\/li>\n<li>Francisco Javier Alvarez-cienfuegos Suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Ariceta Iraola Introduccion: la isquemia intestinal es una patolog\u00eda cada vez m\u00e1s frecuente en nuestros hospitales. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,1279,17749,156,1323],"tags":[10546,58949,11773,107223,1155,107224],"class_list":["post-42760","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-experimental","category-navarra","category-patologia","category-patologia-experimental","tag-daniel-casanova-rituerto","tag-francisco-javier-alvarez-cienfuegos-suarez","tag-javier-diez-Martinez","tag-juan-ariceta-iraola","tag-juan-carlos-garcia-valdecasas-salgado","tag-lera-tricas-jose-m"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42760"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42760\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}