{"id":4278,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/efecto-de-la-diabetes-mellitus-inducida-por-estreptozotocina-sobre-la-expresion-de-igf-i-durante-la-pubertad-en-la-rata\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"efecto-de-la-diabetes-mellitus-inducida-por-estreptozotocina-sobre-la-expresion-de-igf-i-durante-la-pubertad-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-diabetes-mellitus-inducida-por-estreptozotocina-sobre-la-expresion-de-igf-i-durante-la-pubertad-en-la-rata\/","title":{"rendered":"Efecto de la diabetes mellitus inducida por estreptozotocina sobre la expresion de igf-i durante la pubertad en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jose Ortego Rojo <\/strong><\/h2>\n<p>Estudiamos in vivo los efectos de la diabetes mellitus (dm) sobre la regulacion del sistema gh\/igf-i en la rata, durante la pubertad y en diferentes estadios puberales.  utilizamos animales con dm inducida por estreptozotocina, animales diabeticos tratados con insulina y animales controles. La dm produjo un dramatico deterioro del crecimiento prepuberal y puberal, y descenso de los niveles puberales de testosterona libre en suero las alteraciones del crecimiento fueron mediadas por una disminucion de la expresion genica de gh en hipofisis y de los niveles puberales de la gh serica, y por una disminucion de la expresion de igf-i en higado. La disminucion de la gh hipofisaria inducida por la dm se relaciono con un aumento de la expresion de igf-i y de su receptor en hipofisis en las ratas diabeticas. Otras se\u00f1ales reguladoras de gh investigadas (expresion de somatostatina, de igf-i y de su receptor en hipotalamo) no se influyeron por la dm. La dm no provoco cambios en la expresion de igf-i y de su receptor en hemisferios cerebrales. En cambio, indujo una disminucion de la expresion de igf-i asociada a aumento de la expresion de su receptor en ri\u00f1on y y testiculo. El desarrollo puberal normal y las alteraciones metabolicas de la dm se mostraron como se\u00f1ales reguladoras de la expresion de igf-i y de su receptor con especificidad de tejido.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la diabetes mellitus inducida por estreptozotocina sobre la expresion de igf-i durante la pubertad en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la diabetes mellitus inducida por estreptozotocina sobre la expresion de igf-i durante la pubertad en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jose Ortego Rojo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lucinda Cacicedo Egues<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Melchor Alvarez De Mon Soto <\/li>\n<li>Eleuterio Hernandez Miguel (vocal)<\/li>\n<li>Elvira Melian Perez (vocal)<\/li>\n<li>Manuel Rodriguez Zapata (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jose Ortego Rojo Estudiamos in vivo los efectos de la diabetes mellitus (dm) sobre la regulacion del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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