{"id":42805,"date":"2018-03-09T09:44:53","date_gmt":"2018-03-09T09:44:53","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/anticuerpos-anticelula-endotelial-en-las-enfermedades-autoinmunes-sistemicas\/"},"modified":"2018-03-09T09:44:53","modified_gmt":"2018-03-09T09:44:53","slug":"anticuerpos-anticelula-endotelial-en-las-enfermedades-autoinmunes-sistemicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/anticuerpos-anticelula-endotelial-en-las-enfermedades-autoinmunes-sistemicas\/","title":{"rendered":"Anticuerpos anticelula endotelial en las enfermedades autoinmunes sistemicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita Navarro  Lopez <\/strong><\/h2>\n<p>Los anticuerpos anticelula endotelial (aace) son un grupo heterog\u00e9neo de autoanticuerpos dirigidos contra determinantes antig\u00e9nicos de las membranas de las celulas endoteliales (ce). Se han descrito en diversas enfermedades antoinmunes sistemicas y otras entidades que tienen en comun la presencia de lesion vascular. Estos anticuerpos podrian ser los responsables de las alteraciones funcionales de las ce y por tanto podrian desarrollar un papel etiopatogenico en la produccion del da\u00f1o vascular, vasculitico y tromb\u00f3tico presente en estas enfermedades. Se estudiaron 231 pacientes: 107 vasculitis sistemicas primarias(39 con at, 25 con pan, 9 con gw, 34 con eb) 90 con les,15 con saf(9 asociado a les y 9 con safp) y 19 con ssp. Los aace se detectaron mediante tecnica de elisa y como sustrato antigenico ce en cultivo derivadas de vena cordon umbilical humano (macrocirculacion), grasa retroperitoneal humana (microcirculacion) y ce fijadas. Los resultados mas destacados de los trabajos de investigaci\u00f3n que componen esta tesis han sido:  1. Los pacientes con enfermedades autoinmunes sist\u00e9micas tienen una alta preValencia de aace. 2. En el les los aace se asocian con la presencia de lesiones vasculares, nefropatia lupica y aac. 3. En las vasculitis sistemicas primarias especialmente en la enfermedad de behcet, los aace se asocian con la actividad de la enfermedad. En el saf los aace se relacionan con la presencia de aac y con los abgpi, y existe una relaci\u00f3n significativa entre los aace y los fenomenos tromboticos del saf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Anticuerpos anticelula endotelial en las enfermedades autoinmunes sistemicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Anticuerpos anticelula endotelial en las enfermedades autoinmunes sistemicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita Navarro  Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/03\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Ingelmo Mor\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Castillo cofi\u00f1o <\/li>\n<li>miquel Vilardell tarres (vocal)<\/li>\n<li>jaume Martorell pons (vocal)<\/li>\n<li>xavier Montaban gairin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita Navarro Lopez Los anticuerpos anticelula endotelial (aace) son un grupo heterog\u00e9neo de autoanticuerpos dirigidos contra determinantes [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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