{"id":4282,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/autotrasplante-de-medula-osea-en-la-leucemia-aguda-linfoblastica-efectos-hematologicos-e-inmunologicos-del-tratamiento-medular-in-vitro\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"autotrasplante-de-medula-osea-en-la-leucemia-aguda-linfoblastica-efectos-hematologicos-e-inmunologicos-del-tratamiento-medular-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/autotrasplante-de-medula-osea-en-la-leucemia-aguda-linfoblastica-efectos-hematologicos-e-inmunologicos-del-tratamiento-medular-in-vitro\/","title":{"rendered":"Autotrasplante de medula osea en la leucemia aguda linfoblastica. efectos hematologicos e inmunologicos del tratamiento medular in vitro."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez De Oteyza Jaime <\/strong><\/h2>\n<p>Objetivo principal: evaluar el papel del purgado medular con anticuerpos monoclonales y complemento en pacientes con leucemia linfoblastica aguda (lla) sometidos a autotransplante de medula osea (atmo). Metodolog\u00eda: 1) fase experimental de ensayos de citotoxicidad sobre blastos leucemicos marcados con cromo radioactivo. 2) fase clinica de realizacion de atmo en pacientes con lla, previo tratamiento de medula osea \u00abin vitro\u00bb con anticuerpos monoclonales. Controles mediante citometria de flujo y cultivo de precursores hematopoyeticos; resultados: la depleccion media de celulas diana fue del 88%. La eficacia del purgado fue significativamente mejor en los casos de leucemias t (99%) que en las leucemias no t (87%), con una p=0,022. La depleccion se correlaciono con el contenido de celulas diana antes del tratamiento (r=0,63). La duracion de la neutropenia postransplante se vio significativamente acortada en los tratados con g-csf (15 versus 29 dias, p=0,022). La supervivencia actual a 3 a\u00f1os es del 28%, y no se correlaciono con la eficacia del purgado.  conclusion: el atmo con medula purgada tiene valor en el tratamiento de la lla de alto riesgo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Autotrasplante de medula osea en la leucemia aguda linfoblastica. efectos hematologicos e inmunologicos del tratamiento medular in vitro.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Autotrasplante de medula osea en la leucemia aguda linfoblastica. efectos hematologicos e inmunologicos del tratamiento medular in vitro. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez De Oteyza Jaime <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Odriozola Lino<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ana Villegas Martinez <\/li>\n<li>Angel Garcia Avello (vocal)<\/li>\n<li>Emilio Herrera Castillon (vocal)<\/li>\n<li>Melchor Alvarez De Mon Soto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez De Oteyza Jaime Objetivo principal: evaluar el papel del purgado medular con anticuerpos monoclonales y complemento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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