{"id":42822,"date":"2018-03-09T09:44:54","date_gmt":"2018-03-09T09:44:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-sistema-antigenico-hu-implicaciones-en-la-etiopatogenia-de-la-encefalomielitis-neuronopata%c2%ada-sensitiva-paraneoplasica-y-en-el-pronostico-del-carcinoma-microca%c2%adtico-de-pulmon\/"},"modified":"2018-03-09T09:44:54","modified_gmt":"2018-03-09T09:44:54","slug":"el-sistema-antigenico-hu-implicaciones-en-la-etiopatogenia-de-la-encefalomielitis-neuronopata%c2%ada-sensitiva-paraneoplasica-y-en-el-pronostico-del-carcinoma-microca%c2%adtico-de-pulmon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-sistema-antigenico-hu-implicaciones-en-la-etiopatogenia-de-la-encefalomielitis-neuronopata%c2%ada-sensitiva-paraneoplasica-y-en-el-pronostico-del-carcinoma-microca%c2%adtico-de-pulmon\/","title":{"rendered":"El sistema antig\u00e9nico hu: implicaciones en la etiopatogenia de la encefalomielitis\/neuronopat\u00edasensitiva paraneopl\u00e1sica y en el pron\u00f3stico del carcinoma microc\u00edtico de pulm\u00f3n."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Montserrat Tora Barnadas <\/strong><\/h2>\n<p>Los anticuerpos anti-hu constituyen el principal marcador de la encefalomielitis\/neuronopat\u00eda sensitiva paraneopl\u00e1sica que se presenta en un 1% de enfermos con carcinoma microc\u00edtico de pulm\u00f3n(cmp). Los anticuerpos anti-hu reconocen un grupo de prote\u00ednas de 35-40 kda presentes en el n\u00facleo de todas las neuronas normales, de todas las c\u00e9lulas del cmp y del 50% de neuroblastomas. La presencia de anticuerpos a t\u00edtulos bajos de enfermos con cmp se han correlacionado en un estudio preliminar con un curso m\u00e1s indolente del tumor.  en nuestro estudio hemos demostrado mediante inmunofluorescencia, ensayos de absorci\u00f3n, de fraccionamiento subcelular y de biotinilaci\u00f3n superficial, que los anticuerpos anti-hu reconocen prote\u00ednas relacionadas con los ant\u00edgenos hu tambi\u00e9n en la membrana plasm\u00e1tica de lineas de cmp y de neuroblastoma. este hallazgo puede tener implicaciones en la etiopatogenia de la enfermedad paraneopl\u00e1stica, as\u00ed como ser utilizado para futuras estrategias de diagn\u00f3stico y\/o tratamiento.  en segundo lugar, mediante un estudio prospectivo multic\u00e9ntrico hemos demostrado que la presencia de anticuerpos anti-hu a t\u00edtulos bajos en enfermos con cmp se asocia a enfermedad limitada en el momento del diagn\u00f3stico, a respuesta completa al tratamiento anti-neopl\u00e1sico y a una mejor supervivencia.  por \u00faltimo, con la finalidad de detectar enfermedad m\u00ednima residual en enfermos en la fase de remisi\u00f3n completa,hemos optimizado una t\u00e9cnica muy sensible que por rt-pcr sobre los transcritos de hud(uno de los ant\u00edgenos de la familia hu) permite detectar 1 celula hy+\/106 c\u00e9lulas hu-. La utilizaci\u00f3n de esta tecnica permite detectar los transcritos de hud en linfocitos de sangre perif\u00e9rica de individuos sanos y tambi\u00e9n en otros tejidos de origen extraneural. Estos resultados sugieren una posible regulaci\u00f3n posttranscripcional de la expresi\u00f3n de las prote\u00ednas hu.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El sistema antig\u00e9nico hu: implicaciones en la etiopatogenia de la encefalomielitis\/neuronopat\u00edasensitiva paraneopl\u00e1sica y en el pron\u00f3stico del carcinoma microc\u00edtico de pulm\u00f3n.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El sistema antig\u00e9nico hu: implicaciones en la etiopatogenia de la encefalomielitis\/neuronopat\u00edasensitiva paraneopl\u00e1sica y en el pron\u00f3stico del carcinoma microc\u00edtico de pulm\u00f3n. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Montserrat Tora Barnadas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/03\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Xavier Real Arribas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Guardia mass\u00f3 <\/li>\n<li>oriol Bachs valldeneu (vocal)<\/li>\n<li>ricardo Pujol borrell (vocal)<\/li>\n<li>Antonio Garcia de herreros madue\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Montserrat Tora Barnadas Los anticuerpos anti-hu constituyen el principal marcador de la encefalomielitis\/neuronopat\u00eda sensitiva paraneopl\u00e1sica que se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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