{"id":42925,"date":"2018-03-09T09:45:06","date_gmt":"2018-03-09T09:45:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hiperglucemia-y-tratamiento-con-insulina-en-el-trasplante-de-islotes-de-pancreas\/"},"modified":"2018-03-09T09:45:06","modified_gmt":"2018-03-09T09:45:06","slug":"hiperglucemia-y-tratamiento-con-insulina-en-el-trasplante-de-islotes-de-pancreas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/hiperglucemia-y-tratamiento-con-insulina-en-el-trasplante-de-islotes-de-pancreas\/","title":{"rendered":"Hiperglucemia y tratamiento con insulina en el trasplante de islotes de pancreas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Francisco Merino Torres <\/strong><\/h2>\n<p>La hiperglucemia ha demostrado efectos delet\u00e9reos sobre los islotes pancre\u00e1ticos. El objetivo del estudio fue investigar si en el trasplante de islotes de p\u00e1ncreas, mantener la normoglucemia con tratamiento insul\u00ednico, ten\u00eda un efecto beneficioso sobre los islotes trasplantados y estudiar las causas de ese posible efecto beneficioso determinando el efecto sbore la masa, replicaci\u00f3n y funci\u00f3n de las c\u00e9lulas beta trasplantadas. Para ello se utiliz\u00f3 un modelo experimental con ratones c57bl\/6, diab\u00e9ticos con estreptozocina, trasplantados con 100 islotes sing\u00e9nicos, una masa beta insuficiente para conseguir la normoglucemia, tratados o no con insulina en funci\u00f3n del grupo al que pertenec\u00edan. La normoglucemia se consigui\u00f3 en ratones tratados coninsulina con el trasplante de una masa beta insuficiente, y a pesar de una reducci\u00f3n inicial en la masa beta trasplantada. La mejor evoluci\u00f3n se obtuvo cuando el tratamiento con insulina se inici\u00f3 antes del trasplante y se mantuvo durante le periodo de revascularizaci\u00f3n. Los islotes trasplantados en ratones diab\u00e9ticos tratados con insulina de acuerdo con esta pauta, mostraron mejor funci\u00f3n beta y preservaron el contenido en insulina, y fueron capaces de aumentar su masa celular beta en respuesta a un aumente en la demanda matab\u00f3lica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hiperglucemia y tratamiento con insulina en el trasplante de islotes de pancreas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hiperglucemia y tratamiento con insulina en el trasplante de islotes de pancreas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Francisco Merino Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/05\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Soler Ram\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ricardo Pujol borrell <\/li>\n<li>josep Mar\u00eda Griny\u00f3 boira (vocal)<\/li>\n<li> Ponce marco Jos\u00e9 Luis (vocal)<\/li>\n<li>Francisco Pi\u00f1\u00f3n sell\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Francisco Merino Torres La hiperglucemia ha demostrado efectos delet\u00e9reos sobre los islotes pancre\u00e1ticos. El objetivo del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,9,141,10,851,139],"tags":[74762,48992,107518,34085,19380,13791],"class_list":["post-42925","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-ciencias-medicas","category-cirugia","category-cirugia-de-trasplantes","category-endocrinologia","category-medicina-interna","tag-francisco-pinon-selles","tag-josep-maria-grinyo-boira","tag-juan-francisco-merino-torres","tag-juan-soler-ramon","tag-ponce-marco-jose-luis","tag-ricardo-pujol-borrell"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42925","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=42925"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/42925\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=42925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=42925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=42925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}