{"id":4334,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/efecto-del-midazolam-sobre-el-numero-de-neuronas-y-la-cariometria-en-la-rata\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"efecto-del-midazolam-sobre-el-numero-de-neuronas-y-la-cariometria-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-midazolam-sobre-el-numero-de-neuronas-y-la-cariometria-en-la-rata\/","title":{"rendered":"Efecto del midazolam sobre el numero de neuronas y la cariometria en la rata."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Massimiliano Carassiti <\/strong><\/h2>\n<p>El midazolam (m) administrado por via oral durante 120 dias a ratas wistar a la dosis de 1mg\/kg y 3mg\/kg (2 grupos de 20 animales cada uno), no ha producido cambios estadisticamente significativos, con respecto a los animales control (10 ratas), ni en el numero de neuronas ni en la cariometria. Estas modificaciones se han estudiado en el gyrus dentatus y en el asta de ammon (ca1,ca2,ca3 y ca4). Si que se ha apreciado una tendencia a la hipertrofia nuclear en los animales tratados con m, especialmente en los que recibieron 1mg\/kg. El estudio inmunocitoquimico con parvalbumina y calbindina, mostro un marcaje mas intenso de las neuronas en los grupos que fueron tratados con m. En cuanto al comportamiento de las ratas ante el paso de la corriente, se pudo observar una reaccion mas intensa en los animales tratados con m. La evolucion del peso corporal ha mostrado una perdida significativa con respecto a los controles. El midazolam administrado durante largo tiempo (equivalente a 10 a\u00f1os en nuestra especie) a dosis mas elevadas que las utilizadas en clinica, no tiene efectos toxicos en la rata.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del midazolam sobre el numero de neuronas y la cariometria en la rata.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del midazolam sobre el numero de neuronas y la cariometria en la rata. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Massimiliano Carassiti <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gonzalo Sanz  Luis Mar\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Angel Nalda Felipe <\/li>\n<li>Mar\u00eda  Trinidad Herrero Ezquerro (vocal)<\/li>\n<li>Ricardo Insausti Serrano (vocal)<\/li>\n<li>Francisco Carrascosa Moreno (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Massimiliano Carassiti El midazolam (m) administrado por via oral durante 120 dias a ratas wistar a la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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