{"id":4371,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/estructura-del-enhancer-i-del-virus-de-la-hepatitis-b-en-relacion-con-la-respuesta-al-tratamiento-con-interferon-en-hepatitis-cronica-b\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"estructura-del-enhancer-i-del-virus-de-la-hepatitis-b-en-relacion-con-la-respuesta-al-tratamiento-con-interferon-en-hepatitis-cronica-b","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estructura-del-enhancer-i-del-virus-de-la-hepatitis-b-en-relacion-con-la-respuesta-al-tratamiento-con-interferon-en-hepatitis-cronica-b\/","title":{"rendered":"Estructura del \u00abenhancer\u00bb i del virus de la hepatitis b en relacion con la respuesta al tratamiento con interferon en hepatitis cronica b"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Guerra Pinheiro Vieira Reis Helena Margarida <\/strong><\/h2>\n<p>El nivel basal de dna del virus de la hepatitis b (vhb) en suero es el factor predictivo mas importante de la respuesta al tratamiento con interferon (ifn). Por ello se considero el estudio de la estructura y de la funcion del \u00abenhancer-i\u00bb del vhb y su influencia en los niveles del dna viral en pacientes respondedores y no respondedores al tratamiento con ifn. Se estudio el \u00abenhancer-i\u00bb del vhb en 10 pacientes (5 respondedores y 5 no respondedores) con hepatitis cronica activa b. La la region del \u00abenhancer-i\u00bb fue aislada y amplificada del suero de los pacientes y determinada su secuencia.  posteriormente la actividad reguladora de la transcripcion de cada secuencia mutada fue estudiada usando el ensayo cat. Este ensayo fue complementado con ensayos de movilidad electroforetica. En los 3 pacientes no respondedores al tratamiento con genotipo adw, se encontro mutaciones en su secuencia. Asi mismo se encontro tambien una actividad reguladora de la transcripcion significativamente mayor y un patron de union a factores nucleares distinto de los respondedores.  se observo tambien que el ifn modula a algunas proteinas nucleares que se unen al \u00abenhancer-i\u00bb. Estos resultados indican que mutaciones en el \u00abenhancer-i\u00bb influyen los niveles de dna del vhb en suero y en la respuesta al tratamiento con ifn.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura del \u00abenhancer\u00bb i del virus de la hepatitis b en relacion con la respuesta al tratamiento con interferon en hepatitis cronica b<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura del \u00abenhancer\u00bb i del virus de la hepatitis b en relacion con la respuesta al tratamiento con interferon en hepatitis cronica b <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Guerra Pinheiro Vieira Reis Helena Margarida <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas M. Prieto Valtue\u00f1a<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Arturo Gullon Macarron <\/li>\n<li>Mar\u00eda  Jes\u00fas Lopez Zabalza (vocal)<\/li>\n<li>Kamal Chowdhury (vocal)<\/li>\n<li>Benito De Las Heras Ni\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guerra Pinheiro Vieira Reis Helena Margarida El nivel basal de dna del virus de la hepatitis b [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,1085,139,17749],"tags":[17799,10550,18029,15059,18031,18030],"class_list":["post-4371","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-enfermedades-infecciosas","category-medicina-interna","category-navarra","tag-arturo-gullon-macarron","tag-benito-de-las-heras-nino","tag-guerra-pinheiro-vieira-reis-helena-margarida","tag-jesus-m-prieto-valtuena","tag-kamal-chowdhury","tag-maria-jesus-lopez-zabalza"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/4371","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=4371"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/4371\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=4371"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=4371"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=4371"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}