{"id":4372,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/lesion-estereotaxica-del-nucleo-subtalamico-en-el-primate-con-parkinsonismo-experimental\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"lesion-estereotaxica-del-nucleo-subtalamico-en-el-primate-con-parkinsonismo-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/lesion-estereotaxica-del-nucleo-subtalamico-en-el-primate-con-parkinsonismo-experimental\/","title":{"rendered":"Lesion estereotaxica del nucleo subtalamico en el primate con parkinsonismo experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Guridi Legarra <\/strong><\/h2>\n<p>Este trabajo se ha realizado en 24 macacos tratando de analizar el impacto de la lesion del nucleo subtalamico (nst) y el parkinsonismo inducido en los mismos. Los animales se han dividido en tres grupos. Grupo i; animales tratados previamente con mptp y lesion ulterior del nst (n: 10). Grupo ii; animales con lesion del nst y posterior tratamiento con mptp (n: 7). Grupo iii; animales control (n: 3), animales tratados con mptp (n:  3) y un animal con lesion del nst sin tratamiento ulterior.  la lesion del nst en los macacos estudiados ha mostrado una importante mejoria en los parametros motores estudiados. Asi una significativa mejoria de la actividad espontanea, desaparicion del temblor postural contralateral, significativa mejoria en test motores y la existencia de una hemicorea contralateral a la lesion en todos los macacos estudiados con lesion del nst. Por tecnica de hibridacion \u00abin situ\u00bb se ha demostrado un aumento de la expresion gad rnam (glutamato decarboxilasa) en el globo palido medial y sustancia negra pars reticulata en los animales parkinsonianos. Por otro lado la lesion del nst reduce la expresion de gad rnam en ambos nucleos sin llegar a valores considerados como normales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Lesion estereotaxica del nucleo subtalamico en el primate con parkinsonismo experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Lesion estereotaxica del nucleo subtalamico en el primate con parkinsonismo experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Guridi Legarra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 A. Obeso Inchausti<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Gonzalo Sanz  Luis Mar\u00eda <\/li>\n<li>Eduardo Tolosa Sarr\u00f3 (vocal)<\/li>\n<li>Manuel Martinez Lage (vocal)<\/li>\n<li>Demetrio Barcia Salorio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Guridi Legarra Este trabajo se ha realizado en 24 macacos tratando de analizar el impacto de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,139,17749,392,1880],"tags":[463,1286,14536,18032,9920,18033],"class_list":["post-4372","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-medicina-interna","category-navarra","category-neurocirugia","category-neurologia","tag-demetrio-barcia-salorio","tag-eduardo-tolosa-sarro","tag-gonzalo-sanz-luis-maria","tag-jorge-guridi-legarra","tag-jose-a-obeso-inchausti","tag-manuel-Martinez-lage"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/4372","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=4372"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/4372\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=4372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=4372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=4372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}