{"id":44027,"date":"2018-08-23T21:43:31","date_gmt":"2018-08-23T21:43:31","guid":{"rendered":""},"modified":"2018-08-23T21:43:31","modified_gmt":"2018-08-23T21:43:31","slug":"sintesis-y-ensayo-in-vitro-como-inhibidores-de-monoaminooxidasa-de-nuevos-dihidro-y-tetrahidro-piridazino-45-b-indoles-y-2-carbohidracinas-indolicas-35-y-135-sustituidas-estudio-de-relacion-est","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/sintesis-y-ensayo-in-vitro-como-inhibidores-de-monoaminooxidasa-de-nuevos-dihidro-y-tetrahidro-piridazino-45-b-indoles-y-2-carbohidracinas-indolicas-35-y-135-sustituidas-estudio-de-relacion-est\/","title":{"rendered":"Sintesis y ensayo in vitro como inhibidores de monoaminooxidasa de nuevos dihidro y tetrahidro piridazino (4,5-b) indoles y 2-carbohidracinas indolicas 3,5 y 1,3,5 sustituidas. estudio de relacion estructura-actividad."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Martinez Remirez M. Teresa <\/strong><\/h2>\n<p>En este trabajo se han sintetizado: dos series de alquilhidracinas indolicas correspondientes a las estructuras 1-(2-(3 5-dimetilindolil) carbonil)-2-alquilhidracinas y 1-(2-(1 3 5-trimetilildolil) carbonil)-2-alquilhidracinas. Una serie de piridazino (4 5-b) indoles a partir de indoles 2 3-dicarbosustituidos con hidrato de hidracina. Dos series de derivados de piridazinoindoles a partir de 3 4-dihidro-4-oxo-5-metil-piridazino (4 5-b) indol y 1 2 3 4-tetrahidro-1-fenil-4-oxo-5-metil-piridazino (4 5-b) indol  con los reactivos correspondientes. Se han realizado ensayos invitro frente a monoaminooxidasa de todos los compuestos sintetizados con estructura de hidracina. 1-(2-(3 5-dimetilildolil) carbonil)-2-isobutilhidracina  posee un poder de inhibicion del enzima de 20.100 veces mas potente que la iproniazida.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis y ensayo in vitro como inhibidores de monoaminooxidasa de nuevos dihidro y tetrahidro piridazino (4,5-b) indoles y 2-carbohidracinas indolicas 3,5 y 1,3,5 sustituidas. estudio de relacion estructura-actividad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis y ensayo in vitro como inhibidores de monoaminooxidasa de nuevos dihidro y tetrahidro piridazino (4,5-b) indoles y 2-carbohidracinas indolicas 3,5 y 1,3,5 sustituidas. estudio de relacion estructura-actividad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Martinez Remirez M. Teresa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1977<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Monge Vega<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Larralde Berrio <\/li>\n<li>Esteban Santiago Calvo (vocal)<\/li>\n<li> Clavera Armenteros Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Franco Fern\u00e1ndez Gonz\u00e1lez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Martinez Remirez M. Teresa En este trabajo se han sintetizado: dos series de alquilhidracinas indolicas correspondientes a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1412,17749,17,416],"tags":[7150,108665,17968,2841,4826,108681],"class_list":["post-44027","post","type-post","status-publish","format-standard","hentry","category-compuestos-heterociclicos","category-navarra","category-quimica","category-quimica-organica","tag-antonio-monge-vega","tag-clavera-armenteros-jose-maria","tag-esteban-santiago-calvo","tag-franco-fernandez-gonzalez","tag-jesus-larralde-berrio","tag-Martinez-remirez-m-teresa"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/44027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=44027"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/44027\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=44027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=44027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=44027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}