{"id":4772,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/dimetiltiourea-y-diclofenac-sodico-penetracion-transcorneal-e-interaccion-farmacocinetica\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"dimetiltiourea-y-diclofenac-sodico-penetracion-transcorneal-e-interaccion-farmacocinetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/dimetiltiourea-y-diclofenac-sodico-penetracion-transcorneal-e-interaccion-farmacocinetica\/","title":{"rendered":"Dimetiltiourea y diclofenac sodico: penetracion transcorneal e interaccion farmacocinetica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Miquel Lopez <\/strong><\/h2>\n<p>El presente trabajo de tesis se encuadra entre los de tipo experimental, realizado sobre ojos de conejo, tras aplicacion topica de un antioxidante dimetiltiourea (dmtu) y un antiinflamatorio no esteroideo diclofenac sodico (dcfna). Se pretende determinar como penetran a traves de la cornea tanto cuando se administran aislados o de forma conjunta. Para ello utilizamos conejos albinos raza new zealand, solucion de dmtu 0.1 y 1%, dcfna al 0.1%. Nos servimos de un equipo instrumental de cromatografia liquida de alta presion (hplc) para su determinacion.  resultando una mayor persistencia (mas de 1 h) de concentraciones de dmtu en humor acuoso, al asociar dcfna. Por otra parte, aparecen mayores concentraciones en cornea de dcfna que persisten durante la primera hora al asociarlo con dmtu (0.1 y 1%). Los dos compuestos son antiinflamatorios segun dos mecanismos diferentes lo que favorece que se puedan administrar asociados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dimetiltiourea y diclofenac sodico: penetracion transcorneal e interaccion farmacocinetica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dimetiltiourea y diclofenac sodico: penetracion transcorneal e interaccion farmacocinetica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Miquel Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alicante<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alfredo Orts Buch\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Alfonso Puchades Orts <\/li>\n<li>Edmundo Uson Gonzalez (vocal)<\/li>\n<li> Ponce Marco Jos\u00e9 Luis (vocal)<\/li>\n<li> Ruiz Moreno Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Miquel Lopez El presente trabajo de tesis se encuadra entre los de tipo experimental, realizado sobre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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