{"id":47737,"date":"2020-06-10T16:11:24","date_gmt":"2020-06-10T16:11:24","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aportacion-al-estudio-farmacocinetico-y-farmacodinamico-del-sulpiride-en-ratas-y-sus-asociaciones-con-los-antidepresivos-triciclicos\/"},"modified":"2020-06-10T16:11:24","modified_gmt":"2020-06-10T16:11:24","slug":"aportacion-al-estudio-farmacocinetico-y-farmacodinamico-del-sulpiride-en-ratas-y-sus-asociaciones-con-los-antidepresivos-triciclicos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aportacion-al-estudio-farmacocinetico-y-farmacodinamico-del-sulpiride-en-ratas-y-sus-asociaciones-con-los-antidepresivos-triciclicos\/","title":{"rendered":"Aportacion al estudio farmacocinetico y farmacodinamico del sulpiride en ratas y sus asociaciones con los antidepresivos triciclicos"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Arias Gonzalez Jes\u00fas Alfonso <\/strong><\/h2>\n<p>El estudio cinetico del sulpiride (sulp.)  Por via intraperitoneal  presento una curva plasmatica bioexponencial  adaptandose al modelo bicompartimental clasico con t 1\/2 de 15  34   y 1h.23 26  de distribucion y eliminacion respectivamente  deduciendose que el sulp.  se distribuye en un volumen relativamente peque\u00f1o del compartimento periferico  sin retenerse en depositos no acuosos. La administracion simultanea de sulpiride y de triciclicos (ami  imi  doxp)  modifico significativamente la curva del sulp.  Produciendose elentecimientos de las t1\/2 de distribucion y eliminacion. Se estudio el reflejo condicionado de evasion a diferentes dosis de sulp. A los 15  y 3h.  En el animal condicionado  observandose que a las 3h. El sulp. Inhibe en un 60% la respuesta (propiedad neuroleptica). Cuando se asociaron a las dosis de sulp.  los triciclicos  se observo una disminucion de la inhibicion del relejo condicionado a las 3h. De manera significativa. Pudiendo existir una sumacion de los efectos timoanalepticos de ambos compuestos lo que corroboraria los tratamientos de tipo experimental en clinica (sulp + triciclicos) con resultados expectaculares y tratamientos mas cortos y efectivos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aportacion al estudio farmacocinetico y farmacodinamico del sulpiride en ratas y sus asociaciones con los antidepresivos triciclicos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aportacion al estudio farmacocinetico y farmacodinamico del sulpiride en ratas y sus asociaciones con los antidepresivos triciclicos <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Arias Gonzalez Jes\u00fas Alfonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1981<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Emilio Mu\u00f1oz Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Cabo Torres <\/li>\n<li>Jes\u00fas Thomas Gomez (vocal)<\/li>\n<li>Emilio Mu\u00f1oz Fernandez (vocal)<\/li>\n<li>Sergio Erill Saez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Arias Gonzalez Jes\u00fas Alfonso El estudio cinetico del sulpiride (sulp.) Por via intraperitoneal presento una curva plasmatica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957],"tags":[112233,111167,5808,3420,3584],"class_list":["post-47737","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","tag-arias-gonzalez-jesus-alfonso","tag-emilio-munoz-fernandez","tag-jesus-cabo-torres","tag-jesus-thomas-gomez","tag-sergio-erill-saez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/47737","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=47737"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/47737\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=47737"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=47737"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=47737"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}