{"id":50093,"date":"2021-06-06T20:42:14","date_gmt":"2021-06-06T20:42:14","guid":{"rendered":""},"modified":"2021-06-06T20:42:14","modified_gmt":"2021-06-06T20:42:14","slug":"desarrollo-y-caracterizacion-morfologica-de-un-modelo-experimental-de-cirrosis-hepatica-y-hepatitis-fulminante-fisiopatologia-del-hiperinsulinismo-e-insulinresistencia-detectable-en-dichas-situacione","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/desarrollo-y-caracterizacion-morfologica-de-un-modelo-experimental-de-cirrosis-hepatica-y-hepatitis-fulminante-fisiopatologia-del-hiperinsulinismo-e-insulinresistencia-detectable-en-dichas-situacione\/","title":{"rendered":"Desarrollo y caracterizacion morfologica de un modelo experimental de cirrosis hepatica y hepatitis fulminante. fisiopatolog\u00eda del hiperinsulinismo e insulinresistencia detectable en dichas situaciones."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anastasio Cecilia Pascual <\/strong><\/h2>\n<p>Se ha estudiado y caracterizado morfologicamente un modelo experimental de cirrosis hepatica en ratas wistar inducida tras seis semanas de tratamiento con cc14 y fenobarbital. Los higados mostraban una cirrosis hipertrofica  micronodular y poco evolucionada. Asimismo se indujo una hepatitis fulminante (necrosis submasivas) a las dos semanas de tratamiento con cc14 y fenobarbital.  los estudios  in vivo  sobre interaccion de insulina en animales cirroticos evidenciaron: un hiperinsulinismo basal; la captacion especifica hepatica de insulina-i125 el % de insulina-i125 especificamente ligada a las membranas hepaticas y el % de insulina-i125 degradada fue significativamente inferiores que en los controles sin cirrosis  ello es debido a una selectiva disminucion del numero de receptores  sin modificaciones aparentes en la afinidad. Los animales con necrosis submasiva presentan una menor captacion de insulina-i125  y una mayor degradacion.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y caracterizacion morfologica de un modelo experimental de cirrosis hepatica y hepatitis fulminante. fisiopatolog\u00eda del hiperinsulinismo e insulinresistencia detectable en dichas situaciones.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y caracterizacion morfologica de un modelo experimental de cirrosis hepatica y hepatitis fulminante. fisiopatolog\u00eda del hiperinsulinismo e insulinresistencia detectable en dichas situaciones. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anastasio Cecilia Pascual <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1982<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>\u00e1ngel Mara\u00f1\u00f3n Cabello<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Cesar Aguirre Viani <\/li>\n<li>Alfonso Velasco Martin (vocal)<\/li>\n<li>\u00e1ngel Mara\u00f1\u00f3n Cabello (vocal)<\/li>\n<li>Santiago Dur\u00e1n Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anastasio Cecilia Pascual Se ha estudiado y caracterizado morfologicamente un modelo experimental de cirrosis hepatica en ratas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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